Document Detail


Insights into viral transmission at the uterine-placental interface.
MedLine Citation:
PMID:  15817386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During human gestation, viruses can cause intrauterine infections associated with pregnancy complications and fetal abnormalities. The ability of viruses to spread from the infected mother to the fetus arises from the architecture of the placenta, which anchors the fetus to the uterus. Placental cytotrophoblasts differentiate, assume an endothelial phenotype, breach uterine blood vessels and form a hybrid vasculature that amplifies the maternal blood supply for fetal development. Human cytomegalovirus - the major cause of congenital disease - infects the uterine wall and the adjacent placenta, suggesting adaptation for pathogen survival in this microenvironment. Infection of villus explants and differentiating and/or invading cytotrophoblasts offers an in vitro model for studying viruses associated with prenatal infections.
Authors:
Lenore Pereira; Ekaterina Maidji; Susan McDonagh; Takako Tabata
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Trends in microbiology     Volume:  13     ISSN:  0966-842X     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-08     Completed Date:  2005-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Affiliation:
Department of Cell and Tissue Biology, University of California San Francisco, UCSF Box 0422, San Francisco, California, CA 94143, USA. pereira@itsa.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytomegalovirus Infections / congenital,  transmission*,  virology
Female
Fetal Diseases / virology*
Humans
Placenta / virology*
Placental Circulation
Pregnancy
Pregnancy Complications, Infectious / virology*
Uterine Diseases / virology
Uterus / virology*
Virus Diseases / congenital,  transmission*,  virology
Grant Support
ID/Acronym/Agency:
AI46657/AI/NIAID NIH HHS; AI53782/AI/NIAID NIH HHS; EY13683/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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