Document Detail


Insights into a surprising reaction: The microwave-assisted direct esterification of phosphinic acids.
MedLine Citation:
PMID:  22293944     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It is well-known that phosphinic acids do not undergo direct esterifications with alcohols under thermal conditions. However, the esterifications take place under microwave (MW) irradiation due to the beneficial effect of MW. As a comparison, maximum 12-15% conversions were observed on traditional heating. It was proved experimentally that the MW-assisted esterifications are not reversible under the conditions applied that may be the consequence of the hydrophobic medium established by the long chain alcohol/phosphinic ester. Neither the thermodynamic, nor the kinetic data obtained by high level quantum chemical calculations justify the direct esterification of phosphinic acids under thermal conditions. The thermodynamic data show that there is no driving force for the reactions under discussion. As a consequence of the relatively high values of activation enthalpy (102-161 kJ mol(-1)), these esterifications are controlled kinetically. Comparing the energetics of the esterification of phosphinic acids and the preparative results obtained under MW conditions, one can see the potential of the MW technique in the synthesis of phosphinates. During our study, a series of new cyclic phosphinates with lipophilic alkyl groups was synthesized.
Authors:
György Keglevich; Nóra Zsuzsa Kiss; Zoltán Mucsi; Tamás Körtvélyesi
Related Documents :
12168754 - A bis-bithiophene from tridax procumbens l. (asteraceae).
17289094 - Oleanane-type triterpenes from the flowers, pith, leaves, and fruit of tetrapanax papyr...
15921434 - Collagenase inhibitory quinic acid esters from ipomoea pes-caprae.
7760064 - Isolation and structural elucidation of pentacyclic triterpenoids from maprounea africana.
15834714 - Polyglutamic acid (pga) production by bacillus sp. sab-26: application of plackett-burm...
15857214 - Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained fr...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-1
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  -     ISSN:  1477-0539     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary. gkeglevich@mail.bme.hu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tailoring the charge carrier dynamics in ZnO nanowires: the role of surface hole/electron traps.
Next Document:  Phenotyping of pulmonary carcinoids and a Ki-67-based grading approach.