Document Detail

Insights into the role of cell-cell junctions in physiology and disease.
MedLine Citation:
PMID:  24016526     Owner:  NLM     Status:  In-Data-Review    
Contacting cells establish different classes of intricate structures at the cell-cell junctions. These structures are of increasing research interest as they regulate a broad variety of processes in development and disease. Further, in vitro studies are revealing that various cell-cell interaction proteins are involved not only in cell-cell processes but also in many additional aspects of physiology, such as migration and apoptosis. This chapter reviews the basic classification of cell-cell junctional structures and some of their representative proteins. Their roles in development and disease are briefly outlined, followed by a section on contemporary methods for probing cell-cell interactions and some recent developments. This chapter concludes with a few suggestions for potential research directions to further develop this promising area of study.
Qi Wei; Hayden Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International review of cell and molecular biology     Volume:  306     ISSN:  1937-6448     ISO Abbreviation:  Int Rev Cell Mol Biol     Publication Date:  2013  
Date Detail:
Created Date:  2013-09-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475846     Medline TA:  Int Rev Cell Mol Biol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-221     Citation Subset:  IM    
Copyright Information:
© 2013 Elsevier Inc. All rights reserved.
Department of Biomedical Engineering, Columbia University, New York, USA.
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