Document Detail

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases.
MedLine Citation:
PMID:  18640136     Owner:  NLM     Status:  MEDLINE    
5-HT(2A) serotonin receptors are essential molecular targets for the actions of LSD-like hallucinogens and atypical antipsychotic drugs. 5-HT(2A) serotonin receptors also mediate a variety of physiological processes in peripheral and central nervous systems including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. Scaffolding proteins have emerged as important regulators of 5-HT(2A) receptors and our recent studies suggest multiple scaffolds exist for 5-HT(2A) receptors including PSD95, arrestin, and caveolin. In addition, a novel interaction has emerged between p90 ribosomal S6 kinase and 5-HT(2A) receptors which attenuates receptor signaling. This article reviews our recent studies and emphasizes the role of scaffolding proteins and kinases in the regulation of 5-HT(2A) trafficking, targeting and signaling.
John A Allen; Prem N Yadav; Bryan L Roth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-02
Journal Detail:
Title:  Neuropharmacology     Volume:  55     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-04-14     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  961-8     Citation Subset:  IM    
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MeSH Terms
Arrestin / metabolism*
Caveolins / metabolism*
Endocytosis / physiology
Intracellular Signaling Peptides and Proteins / metabolism*
Models, Biological
Protein Transport / physiology
Receptor, Serotonin, 5-HT2A / physiology*
Ribosomal Protein S6 Kinases, 90-kDa / metabolism*
Grant Support
R01 MH057635/MH/NIMH NIH HHS; R01 MH057635-13/MH/NIMH NIH HHS; R01MH61887/MH/NIMH NIH HHS; T32HD040127/HD/NICHD NIH HHS; U19 MH082441/MH/NIMH NIH HHS; U19 MH082441-01/MH/NIMH NIH HHS; U19 MH082441-019003/MH/NIMH NIH HHS; U19 MH082441-02/MH/NIMH NIH HHS; U19 MH082441-020001/MH/NIMH NIH HHS; U19 MH082441-029003/MH/NIMH NIH HHS; U19MH82441/MH/NIMH NIH HHS
Reg. No./Substance:
0/Arrestin; 0/Caveolins; 0/Intracellular Signaling Peptides and Proteins; 0/Receptor, Serotonin, 5-HT2A; EC Protein S6 Kinases, 90-kDa

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