| Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte-associated inflammation and neurotoxicity. | |
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MedLine Citation:
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PMID: 10204569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the first description of Alzheimer's disease (AD) in 1907, significant progress was made into understanding disease pathophysiology. The enormous effort in AD research has translated into the discovery of genetic linkages for disease, into elucidating the structure and function of the etiologic beta-amyloid protein, and into unraveling the seemingly complex neuroimmunological cascade that affects neuronal dysfunction. Although effective therapies do not currently exist, many are being developed. We propose that the neuropathogenesis of AD, in measure, revolves around the immunological activation of glial cells, which in turn leads to alterations in inflammatory neurotoxin production, and ultimately to neuronal injury and death. Elucidating the mechanisms involved in such glial cell immune activation should provide valuable insights into understanding the disease process and in providing effective therapeutics to prevent and/or retard the devastating neurodegeneration that afflicts so many of our elderly. |
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Authors:
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R L Cotter; W J Burke; V S Thomas; J F Potter; J Zheng; H E Gendelman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 65 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-04-29 Completed Date: 1999-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 416-27 Citation Subset: IM |
Affiliation:
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The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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epidemiology,
immunology*,
pathology* Animals Humans Inflammation / immunology Leukocytes, Mononuclear / immunology* Neurodegenerative Diseases / immunology* Neurotoxins / immunology Phagocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Neurotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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