| Insights into the establishment of left-right asymmetries in vertebrates. | |
| | |
MedLine Citation:
|
PMID: 18546333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The body-plan of vertebrates, while exteriorly essentially symmetric along its medio-lateral plane, displays numerous left-right differences in the disposition and placement of internal organs. Such left-right asymmetries, established during embryogenesis, are controlled by complex epigenetic and genetic cascades that impart laterality information to the different embryo structures and organ primordia. A key and evolutionarily conserved feature of these information cascades among vertebrate embryos is the left-sided transfer of information from the node to the lateral plate mesoderm during early somitogenesis stages. We review here recent evidence concerning the mechanisms that regulate the laterality of such transfer. Furthermore, we propose a model of left-right axis specification that underscores the role of the node as an integrator of laterality information and the evolutionary conservation of the mechanisms that convey such information to and from the node. |
| | |
Authors:
|
Angel Raya; Juan Carlos Izpisúa Belmonte |
Related Documents
:
|
7317843 - Effect of disopyramide and disobutamide on conduction in perfused rabbit hearts. 9568353 - Intelligent computer reporting 'lack of experience': a confidence measure for decision ... 22293023 - Notch signaling as an important mediator of cardiac repair and regeneration after myoca... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Birth defects research. Part C, Embryo today : reviews Volume: 84 ISSN: 1542-9768 ISO Abbreviation: Birth Defects Res. C Embryo Today Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-06-24 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101167665 Medline TA: Birth Defects Res C Embryo Today Country: United States |
Other Details:
|
Languages: eng Pagination: 81-94 Citation Subset: IM |
Copyright Information:
|
(c) 2008 Wiley-Liss, Inc. |
Affiliation:
|
Center of Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08029 Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Patterning / physiology Embryo, Mammalian / physiology Embryo, Nonmammalian / physiology Embryonic Development Functional Laterality / physiology* Mammals / embryology*, genetics Mesoderm Morphogenesis Species Specificity Vertebrates / embryology*, genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification o...
Next Document: Fluid dynamics of establishing left-right patterning in development.