Document Detail


Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell.
MedLine Citation:
PMID:  19809798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic beta cells has traditionally been considered to be the mitochondrial electron transport chain. While this source is undoubtedly important, we fully describe in this article recent information and evidence of NADPH oxidase-dependent generation of ROS in pancreatic beta cells and identify the various isoforms that contribute to O(2)(*-) and H(2)O(2) production in various conditions. While glucose-stimulated ROS generation may be important for acute regulation of insulin secretion, at higher levels ROS may disrupt mitochondrial energy metabolism. However, ROS may alter other cellular processes such as signal transduction, ion fluxes and/or cell proliferation/death. The various beta cell isoforms of NADPH oxidase (described in this review) may, via differences in the kinetics and species of ROS generated, positively and negatively regulate insulin secretion and cell survival.
Authors:
P Newsholme; D Morgan; E Rebelato; H C Oliveira-Emilio; J Procopio; R Curi; A Carpinelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-10-07
Journal Detail:
Title:  Diabetologia     Volume:  52     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2489-98     Citation Subset:  IM    
Affiliation:
UCD School of Biomolecular and Biomedical Science, UCD Conway Institute and Health Sciences Centre, UCD Dublin, Belfield, Dublin 4, Ireland. philip.newsholme@ucd.ie
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MeSH Terms
Descriptor/Qualifier:
Cell Membrane / enzymology
Diabetes Mellitus / physiopathology
Glucose / metabolism
Homeostasis
Humans
Insulin / secretion
Insulin-Secreting Cells / enzymology*,  physiology
Isoenzymes / metabolism
NADPH Oxidase / metabolism*
Oxidation-Reduction
Phosphorylation
Reactive Oxygen Species / metabolism
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Reactive Oxygen Species; 11061-68-0/Insulin; 50-99-7/Glucose; EC 1.6.3.1/NADPH Oxidase

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