Document Detail


Insights into the biology of cord blood stem/progenitor cells.
MedLine Citation:
PMID:  21481045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To review information on cord blood banking and transplantation with respect to the author's studies, and in context of this field of investigation.
RESULTS: Cord blood transplantation has been successfully used to treat a number of malignant and non-malignant disorders. However, this technique is still associated with limited numbers of cells for transplantation, and with delayed engraftment of neutrophils and platelets. The field of cord blood transplantation will benefit from enhanced and mechanistically based information on haematopoietic stem cell function and potential means to enhance its effectiveness are reviewed. This includes notions concerning possibility of retrieving more cells from the placenta and cord blood, to expand haematopoietic stem cells ex vivo and to increase efficiency of homing and engraftment of these cells. Also discussed are cryopreservation and long-term storage of cord blood haematopoietic and progenitor cells, and new laboratory findings and animal studies for non-haematopoietic uses of cord blood.
Authors:
H E Broxmeyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell proliferation     Volume:  44 Suppl 1     ISSN:  1365-2184     ISO Abbreviation:  Cell Prolif.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-05-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  9105195     Medline TA:  Cell Prolif     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-9     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Banks / methods*
Blood Preservation / methods
Cord Blood Stem Cell Transplantation / methods
Fetal Blood / cytology*,  transplantation*
Hematopoietic Stem Cell Transplantation / methods
Humans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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