| Insights on blastomere nuclearity. | |
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MedLine Citation:
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PMID: 17180469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To analyze the results of our transferred embryos, especially those that "changed" their blastomere nuclearity from Multinucleated (MN) to Mono-nucleated during development. METHODS: Pregnancies where at least one MN embryo was transferred were retrospectively evaluated and categorized in order to record and follow-up on the ones that were implanted. Embryos were classified as normal (when all blastomeres were mono-nucleated on day one and two of development), corrected (multinucleated embryos on day one that became mono-nucleated on day two) and non-corrected (multinucleated either on day one, on day two or both days). RESULTS: There were 633 transfer cycles analyzed. Thirty-three percent (206) had at least one embryo with a MN blastomere at a given stage of development. Pregnancy and implantation rates were 29.0% and 19.0% for the group of exclusively mono-nucleated embryo transfers, and 28.6% and 15.8% for the group with at least one MN embryo transferred. The pregnancy outcome for "corrected" and "non-corrected" embryos could be corroborated unequivocally in only 9 cases, with an outcome of 8 and 4 normal babies, respectively. CONCLUSIONS: Because the amount of data analyzed is not satisfactorily large, differences were not significantly different; however, a trend may exist showing that normal at term pregnancies obtained from corrected embryos are more likely to occur than those from non-corrected embryos. Nuclear observation on a daily basis should be one of the strategies used to select the best embryos for transferring, to improve implantation rates and avoid multiple pregnancies. |
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Authors:
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Mónica Gil; Gustavo D'Ommar; Maria E Póo; Anna Sosa; Marta Piras; Romano Piras; Francisco Rísquez |
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Publication Detail:
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Type: Journal Article Date: 2006-12-16 |
Journal Detail:
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Title: Journal of assisted reproduction and genetics Volume: 24 ISSN: 1058-0468 ISO Abbreviation: J. Assist. Reprod. Genet. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-03-28 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 9206495 Medline TA: J Assist Reprod Genet Country: United States |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Affiliation:
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Clínica de Fertilidad, Centro Médico Docente La Trinidad, Caracas, Venezuela. mgilco@cantv.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blastomeres
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cytology* Cell Nucleus* Embryo Transfer* Embryo, Mammalian / cytology Embryonic Development Female Humans Pregnancy Pregnancy Outcome |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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