Document Detail


Insights into fetal and neonatal development through analysis of cell-free RNA in body fluids.
MedLine Citation:
PMID:  20851538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of cell-free nucleic acids in the circulation of pregnant women for noninvasive prenatal diagnosis is arguably one of the hottest current topics in prenatal medicine. Between 1997 and the present era this field has gone from basic research to clinical application for diagnosis of fetal gender and Rhesus D status. Over the next few years it is likely that noninvasive prenatal diagnosis for Down syndrome will also be possible. Here we summarize current and future clinical applications of analyzing cell-free fetal DNA and RNA in both maternal and neonatal body fluids, including maternal plasma, serum, whole blood, amniotic fluid, and neonatal saliva. We describe methods to evaluate normal and abnormal fetal and neonatal development using gene expression microarrays. We also discuss the ways in which differentially-regulated gene lists can advance knowledge of both fetal and neonatal biology, as well as suggest novel possibilities for fetal and neonatal treatment.
Authors:
Diana W Bianchi; Jill L Maron; Kirby L Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-09-18
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2011-02-15     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  747-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid
Body Fluids / chemistry*
Child Development / physiology*
DNA / analysis
Female
Fetal Development / genetics*
Fetus / physiology
Humans
Infant, Newborn
Pregnancy
Prenatal Diagnosis
RNA / analysis*
Saliva / chemistry
Grant Support
ID/Acronym/Agency:
K08HD059819-02/HD/NICHD NIH HHS; R01 HD042053/HD/NICHD NIH HHS; R01HD42053-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA
Comments/Corrections

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