| Insights into fetal and neonatal development through analysis of cell-free RNA in body fluids. | |
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MedLine Citation:
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PMID: 20851538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The use of cell-free nucleic acids in the circulation of pregnant women for noninvasive prenatal diagnosis is arguably one of the hottest current topics in prenatal medicine. Between 1997 and the present era this field has gone from basic research to clinical application for diagnosis of fetal gender and Rhesus D status. Over the next few years it is likely that noninvasive prenatal diagnosis for Down syndrome will also be possible. Here we summarize current and future clinical applications of analyzing cell-free fetal DNA and RNA in both maternal and neonatal body fluids, including maternal plasma, serum, whole blood, amniotic fluid, and neonatal saliva. We describe methods to evaluate normal and abnormal fetal and neonatal development using gene expression microarrays. We also discuss the ways in which differentially-regulated gene lists can advance knowledge of both fetal and neonatal biology, as well as suggest novel possibilities for fetal and neonatal treatment. |
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Authors:
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Diana W Bianchi; Jill L Maron; Kirby L Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-09-18 |
Journal Detail:
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Title: Early human development Volume: 86 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2011-02-15 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 747-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Mother Infant Research Institute at Tufts Medical Center, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111, USA. dbianchi@tuftsmedicalcenter.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid Body Fluids / chemistry* Child Development / physiology* DNA / analysis Female Fetal Development / genetics* Fetus / physiology Humans Infant, Newborn Pregnancy Prenatal Diagnosis RNA / analysis* Saliva / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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K08HD059819-02/HD/NICHD NIH HHS; R01 HD042053-07/HD/NICHD NIH HHS; R01 HD042053-08/HD/NICHD NIH HHS; R01 HD042053-09/HD/NICHD NIH HHS; R01HD42053-07/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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