Document Detail


Insight to the pathophysiology of stable angina pectoris.
MedLine Citation:
PMID:  23016715     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Atherosclerosis is a chronic disease which mainly represents an inflammatory response in the vessels. Myocardial ischemia manifested by angina pectoris can be either acute or chronic and usually is a result of imbalance between myocardial oxygen supply and myocardial oxygen demand. Chronic stable angina is chest discomfort attributed to myocardial ischemia without the presence of necrosis and is the most common symptom encountered by emergency room physicians. A growing amount of data has shown that endothelial dysfunction, is now considered an important early event in the development of atherosclerosis, while in the absence of angiographically obstructive coronary artery disease, anginal chest pain is often attributed to microvascular coronary dysfunction. Moreover, atheroma formation and in turn, atherosclerotic plaques seem to affect coronary flow, given that multivessel flow-limiting obstructions are observed in patients with chronic coronary syndrome. Morphological changes of diseased arteries related to significant atherosclerosis, such as vascular remodeling may also result in stable angina or claudication. However, several issues with respect to the comprehension of the pathophysiology of the chronic coronary syndrome have not been fully elucidated.
Authors:
Dimitris Tousoulis; Emmanuel Androulakis; Anna Kontogeorgou; Nikolaos Papageorgiou; Marietta Charakida; Katerina Siama; George Latsios; Gerasimos Siasos; Anna-Maria Kampoli; Panagiotis Tourikis; Kostas Tsioufis; Christodoulos Stefanadis
Related Documents :
20825795 - Young patients with chest pain: 1-year outcomes.
8800025 - Cardiac complications in noncardiac surgery: relative value of resting two-dimensional ...
10832825 - Diltiazem in acute myocardial infarction treated with thrombolytic agents: a randomised...
24743925 - The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic...
22783195 - Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arr...
7677545 - Attenuation of myocardial ischemia-reperfusion injury with nitric oxide replacement the...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-18
Journal Detail:
Title:  Current pharmaceutical design     Volume:  -     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Athens University Medical School Hippokration Hospital, Vasilissis Sofias 114 115 28, Athens, Greece. drtousoulis@hotmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heart rate as a therapeutic target in angina pectoris.
Next Document:  Targeting myocardial metabolism for the treatment of stable angina.