| Insight to the pathophysiology of stable angina pectoris. | |
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MedLine Citation:
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PMID: 23016715 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Atherosclerosis is a chronic disease which mainly represents an inflammatory response in the vessels. Myocardial ischemia manifested by angina pectoris can be either acute or chronic and usually is a result of imbalance between myocardial oxygen supply and myocardial oxygen demand. Chronic stable angina is chest discomfort attributed to myocardial ischemia without the presence of necrosis and is the most common symptom encountered by emergency room physicians. A growing amount of data has shown that endothelial dysfunction, is now considered an important early event in the development of atherosclerosis, while in the absence of angiographically obstructive coronary artery disease, anginal chest pain is often attributed to microvascular coronary dysfunction. Moreover, atheroma formation and in turn, atherosclerotic plaques seem to affect coronary flow, given that multivessel flow-limiting obstructions are observed in patients with chronic coronary syndrome. Morphological changes of diseased arteries related to significant atherosclerosis, such as vascular remodeling may also result in stable angina or claudication. However, several issues with respect to the comprehension of the pathophysiology of the chronic coronary syndrome have not been fully elucidated. |
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Authors:
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Dimitris Tousoulis; Emmanuel Androulakis; Anna Kontogeorgou; Nikolaos Papageorgiou; Marietta Charakida; Katerina Siama; George Latsios; Gerasimos Siasos; Anna-Maria Kampoli; Panagiotis Tourikis; Kostas Tsioufis; Christodoulos Stefanadis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-18 |
Journal Detail:
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Title: Current pharmaceutical design Volume: - ISSN: 1873-4286 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Athens University Medical School Hippokration Hospital, Vasilissis Sofias 114 115 28, Athens, Greece. drtousoulis@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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