| Insight, symptoms and neurocognition in bipolar I patients. | |
| | |
MedLine Citation:
|
PMID: 16442637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Level of insight and its relationship to clinical variables and neurocognitive functions was assessed in bipolar I patients. METHODS: Verbal memory, executive functioning, sustained attention, general intelligence and other neurocognitive functions were compared between 37 chronic in- and outpatients and 31 matched normal controls. Detailed psychiatric interviews were completed to define the level of symptomatology and psychosocial functioning. Insight was assessed by the Scale to Assess Unawareness of Mental Disorder (SUMD). RESULTS: Seventy percent of the patients were classified as having impaired insight. Prevalence of impaired insight was 47% and 94% in remitted and symptomatic patients, respectively. Symptomatic patients scored significantly below remitted patients on insight and neurocognition. Illness and symptom unawareness were related to overall level of symptoms, measures of memory, conceptual ability and right hand psychomotor speed and accuracy. Misattribution of symptoms and signs was correlated to visuomotor speed and visuospatial performance in addition to affective symptoms and thought disturbance. CONCLUSIONS: Our findings support the hypothesis that impaired insight and other neurocognitive dysfunctions were present in a large percentage of cases among symptomatic as well as remitted bipolar patients. This may be of clinical relevance and raises important questions about the course and outcome of the illness. |
| | |
Authors:
|
M Varga; A Magnusson; K Flekkøy; U Rønneberg; S Opjordsmoen |
Related Documents
:
|
2140377 - Antidepressant treatment and the occurrence of mania in bipolar patients admitted for d... 10824667 - Cognitive vulnerability in patients with bipolar disorder. 6711347 - Family environments of depressed outpatients. 11018227 - Bipolar depression: pharmacotherapy and related therapeutic strategies. 2511967 - Do treatment protocols improve end results? a study of survival of patients with multip... 8077167 - The spectrum of depressive phenomena after spousal bereavement. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-26 |
Journal Detail:
|
Title: Journal of affective disorders Volume: 91 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-21 Completed Date: 2006-10-04 Revised Date: 2009-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
|
Department of Neuropsychology and Rehabilitation, Ulleval University Hospital, 0407 Oslo, Norway. m.varga@akersykehus.no |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Ambulatory Care Awareness* Bipolar Disorder / diagnosis*, psychology Chronic Disease Cognition Disorders / diagnosis*, psychology Female Humans Interview, Psychological Male Middle Aged Neuropsychological Tests* Patient Admission Personality Inventory Psychiatric Status Rating Scales Reference Values Sick Role Social Adjustment |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Application of multiline two-photon microscopy to functional in vivo imaging.
Next Document: Can personality assessment predict future depression? A twelve-month follow-up of 631 subjects.