Document Detail

Insight and resistance in patients with obsessive-compulsive disorder.
MedLine Citation:
PMID:  11244376     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the degree of insight and resistance in a sample of obsessive-compulsive patients, and the predictive value of poor insight with respect to response to treatment with serotonin reuptake inhibitors (SRIs). Ninety-three patients fulfilling DSM-IV criteria for obsessive-compulsive disorder were evaluated. Seventy patients were treated with an SRI in a 24-week open-label trial. Sixteen percent of the patients did not recognize obsessions and compulsions as unreasonable or senseless. Fifty-two percent of the patients did not try to resist, 72% had little or no control over obsessions, and 64% were not able to exercise an effective control over compulsions. Patients with poor insight had a greater severity of obsessive-compulsive symptoms, a higher rate of schizophrenia spectrum disorders in their first-degree relatives and a higher frequency of a history of psychiatric disorders during childhood. Fifty-two percent of the patients with normal insight responded to SRIs, whereas none of the patients with poor insight were found to be responders. These results suggest the utility of the assessment of insight and resistance in obsessive-compulsive patients, also for the prediction of response to treatment with SRIs.
F Catapano; R Sperandeo; F Perris; M Lanzaro; M Maj
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychopathology     Volume:  34     ISSN:  0254-4962     ISO Abbreviation:  Psychopathology     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8401537     Medline TA:  Psychopathology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Department of Psychiatry, First Medical School, University of Naples, Italy.
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MeSH Terms
Drug Administration Schedule
Drug Resistance
Middle Aged
Obsessive-Compulsive Disorder / diagnosis*,  drug therapy,  psychology*
Predictive Value of Tests
Self Concept*
Serotonin Uptake Inhibitors / administration & dosage,  therapeutic use
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Serotonin Uptake Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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