Document Detail

Insight into the widespread problem of nonadherence to therapy in ulcerative colitis patients.
MedLine Citation:
PMID:  20594140     Owner:  NLM     Status:  MEDLINE    
Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-aminosalicylic acid, which is available in several different formulations and dosing schedules. Several studies have demonstrated that adherence rates to prescribed 5-aminosalicylic acid products are below those expected for a drug that has significant consequences on important outcomes. Worse disease outcomes, higher medical costs and even potentially higher rates of colorectal cancer have been associated with nonadherence. Nonadherence is multifactorial, fluid in nature over time and is dependent on disease activity level. Interventions to improve adherence rates have to be individualized. With the advent of simpler dosing regimens it was assumed that adherence rates would improve, but this has not been the case. Despite our current knowledge about nonadherence, it remains difficult to manage long term.
Steven J Bernick; Sunanda Kane
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  6     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-02     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  677-82     Citation Subset:  IM    
Department of Gastroenterology, Naval Medical Center, San Diego, CA, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Colitis, Ulcerative / drug therapy*
Mesalamine / therapeutic use*
Patient Compliance / statistics & numerical data*
Physician's Role
Physician-Patient Relations
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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