| Insight into glycyrrhetinic acid: the role of the hydroxyl group on liver targeting. | |
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MedLine Citation:
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PMID: 20813176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two kinds of glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles (CTS/PEG-GA NPs) were prepared by an ionic gelation process in which the liver targeting ligand glycyrrhetinic acid (GA) was introduced into the nanoparticles at the C(30)-carboxyl group (CTS/PEG-GA(c) NPs) or the C(3)-hydroxyl group (CTS/PEG-GA(h) NPs). Their characteristics, especially their ability to target the liver, were compared. The results showed that both the CTS/PEG-GA(c) NPs and the CTS/PEG-GA(h) NPs are remarkably targeted to the liver. The accumulation in the liver is 51.3% and 56.5% of the injected dose for the CTS/PEG-GA(c)(4.60%) NPs (the subscript number denotes the GA content as weight percent in nanoparticles) and the CTS/PEG-GA(h)(4.57%) NPs at 3 h after injection, respectively. This is nearly 2.6-2.8 times higher than that obtained with the CTS/PEG NPs. According to our results, there is no significant difference between the CTS/PEG-GA(c) NPs and the CTS/PEG-GA(h) NPs in their ability to target the liver, when they were formed under identical conditions. This indicated that the C(3)-hydroxyl group in GA has little influence on the targeting ability. |
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Authors:
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Qin Tian; Xiuhua Wang; Wei Wang; Chuangnian Zhang; Yuan Liu; Zhi Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 400 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chitosan / chemistry*, pharmacokinetics Drug Carriers / administration & dosage, chemistry*, pharmacokinetics Glycyrrhetinic Acid / chemistry*, pharmacokinetics Liver / metabolism* Mice Nanoparticles Polyethylene Glycols / chemistry*, pharmacokinetics Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Polyethylene Glycols; 471-53-4/Glycyrrhetinic Acid; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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