Document Detail

Insertion sequences and tandem repetitions as sources of variation in a dispersed repeat family.
MedLine Citation:
PMID:  6302288     Owner:  NLM     Status:  MEDLINE    
Sequencing of ten clones from the major dispersed repeat family of mouse (MIF-1) has identified two novel types of sequence variation. Two clones contain small insertion sequences that are flanked by five base-pair duplications of the target site. A third clone, MIFC70, contains a 20 base-pair insertion composed of four direct repeats of a five base-pair sequence. This insertion may have arisen by successive out-of-register pairing and cross-over events at an ancestral target sequence. MIFC70 is also distinguished by its divergence from the standard MIF-1 sequence; whereas for standard clones of the MIF-1 family inter-copy divergence does not exceed 10%, the divergence between MIFC70 and standard clones is of the order of 26%. MIFC70 may represent an aberrant copy which is now isolated from the bulk of the repeat family and is free to diverge.
S D Brown; M Piechaczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular biology     Volume:  165     ISSN:  0022-2836     ISO Abbreviation:  J. Mol. Biol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985088R     Medline TA:  J Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/K00582;  K00583;  K00584;  K00585;  K00586;  K00587;  K00588;  K00589;  K00590;  K00591
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MeSH Terms
Base Composition
Base Sequence
Cloning, Molecular
DNA Restriction Enzymes
DNA Transposable Elements*
DNA, Recombinant
Genetic Variation
Mice, Inbred Strains
Repetitive Sequences, Nucleic Acid*
Reg. No./Substance:
0/DNA Transposable Elements; 0/DNA, Recombinant; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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