| Insertion sequences and tandem repetitions as sources of variation in a dispersed repeat family. | |
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MedLine Citation:
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PMID: 6302288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sequencing of ten clones from the major dispersed repeat family of mouse (MIF-1) has identified two novel types of sequence variation. Two clones contain small insertion sequences that are flanked by five base-pair duplications of the target site. A third clone, MIFC70, contains a 20 base-pair insertion composed of four direct repeats of a five base-pair sequence. This insertion may have arisen by successive out-of-register pairing and cross-over events at an ancestral target sequence. MIFC70 is also distinguished by its divergence from the standard MIF-1 sequence; whereas for standard clones of the MIF-1 family inter-copy divergence does not exceed 10%, the divergence between MIFC70 and standard clones is of the order of 26%. MIFC70 may represent an aberrant copy which is now isolated from the bulk of the repeat family and is free to diverge. |
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Authors:
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S D Brown; M Piechaczyk |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular biology Volume: 165 ISSN: 0022-2836 ISO Abbreviation: J. Mol. Biol. Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-06-23 Completed Date: 1983-06-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985088R Medline TA: J Mol Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 249-56 Citation Subset: IM |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/K00582; K00583; K00584; K00585; K00586; K00587; K00588; K00589; K00590; K00591 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Composition Base Sequence Cloning, Molecular DNA DNA Restriction Enzymes DNA Transposable Elements* DNA, Recombinant Genetic Variation Mice Mice, Inbred Strains Repetitive Sequences, Nucleic Acid* |
| Chemical | |
Reg. No./Substance:
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0/DNA Transposable Elements; 0/DNA, Recombinant; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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