Document Detail

Insect sting anaphylaxis.
MedLine Citation:
PMID:  17493502     Owner:  NLM     Status:  MEDLINE    
Anaphylaxis to insect stings has occurred in 3% of adults and can be fatal even on the first reaction. Large local reactions are more frequent but rarely dangerous. The chance of a systemic reaction to a sting is low (5% to 10%) in large local reactors and in children with mild (cutaneous) systemic reactions, and varies between 25% and 70% in adults depending on the severity of previous sting reactions. Venom skin tests are most accurate for diagnosis, but the radioallergosorbent test (RAST) is an important complementary test. The degree of sensitivity on skin test or RAST does not predict the severity of a sting reaction reliably. Venom sensitization can be detected in 25% of adults, so the history is most important. Venom immunotherapy is 75% to 98% effective in preventing sting anaphylaxis. Most patients can discontinue treatment after 5 years, with very low residual risk of a severe sting reaction.
David B K Golden
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  27     ISSN:  0889-8561     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-07-16     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-72, vii     Citation Subset:  IM    
Johns Hopkins University, 733 North Broadway, Baltimore, MD 21205, USA.
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MeSH Terms
Anaphylaxis / diagnosis*,  etiology*,  prevention & control
Desensitization, Immunologic
Diagnosis, Differential
Insect Bites and Stings / complications*,  diagnosis*,  immunology
Grant Support
5M01-RR02719/RR/NCRR NIH HHS; AI08270/AI/NIAID NIH HHS; M01 RR002719-215802/RR/NCRR NIH HHS; M01 RR002719-215803/RR/NCRR NIH HHS; M01 RR002719-215812/RR/NCRR NIH HHS; R01 AI008270-38/AI/NIAID NIH HHS

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