Document Detail

Insect growth inhibition by tocotrienols and hydroquinones from Roldana barba-johannis.
MedLine Citation:
PMID:  15280003     Owner:  NLM     Status:  MEDLINE    
The methanol extract from the aerial parts of Roldana barba-johannis (Asteraceae) afforded sargachromenol, sargahydroquinoic acid, and sargaquinoic acid. These natural products and their corresponding acetylated and methylated derivatives showed insecticidal and insect growth regulatory activities against the Fall Armyworm [Spodoptera frugiperda J.E. Smith, (Lepidoptera: Noctuidae)], an important insect pest of corn. The most active compounds were sargachromenol and its acetylated derivative; sargahydroquinoic acid and its acetylated derivative; and a mixture of sargachromenol, sargahydroquinoic acid, and sargaquinoic acid (6:3:1) and the acetylated form of this mixture. All these compounds and mixtures had significant inhibitory effects between 5.0 and 20.0 ppm in diets. Most compounds were insecticidal to larvae, with lethal doses between 20 and 35 ppm. In addition, these substances also demonstrated scavenging properties toward 2,2-diphenyl-1-picrylhydrazyl radical in TLC autographic and spectrophotometric assays. These compounds appear to have selective effects on the pre-emergence metabolism of the insect. The results from these compounds were fully comparable in activity to those known natural insect growth inhibitors such as gedunin and methanol extracts of Cedrela salvadorensis and Yucca periculosa. These substances may be useful as natural insecticidal agents.
Carlos L Céspedes; Patricio Torres; Juan C Marín; Amira Arciniegas; Alfonso Romo de Vivar; Ana L Pérez-Castorena; Eduardo Aranda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemistry     Volume:  65     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1963-75     Citation Subset:  IM    
Chemical Ecology Lab-2C, Natural Products Department, Chemistry Institute, Universidad Nacional Autónoma de México, Av. Universidad 3000, Coyoacán 04510, México.
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MeSH Terms
Asteraceae / chemistry*
Hydroquinones / pharmacology*
Insecticides / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts / pharmacology
Spodoptera / drug effects*,  growth & development
Tocotrienols / pharmacology*
Reg. No./Substance:
0/Hydroquinones; 0/Insecticides; 0/Plant Extracts; 0/Tocotrienols

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