| Insect chitinase and chitinase-like proteins. | |
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MedLine Citation:
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PMID: 19816755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insect chitinases belong to family 18 glycosylhydrolases that hydrolyze chitin by an endo-type of cleavage while retaining the anomeric beta-(1-->4) configuration of products. There are multiple genes encoding chitinases and chitinase-like proteins in all insect species studied using bioinformatics searches. These chitinases differ in size, domain organization, physical, chemical and enzymatic properties, and in patterns of their expression during development. There are also differences in tissue specificity of expression. Based on a phylogenetic analysis, insect chitinases and chitinase-like proteins have been classified into several different groups. Results of RNA interference experiments demonstrate that at least some of these chitinases belonging to different groups serve non-redundant functions and are essential for insect survival, molting or development. Chitinases have been utilized for biological control of insect pests on transgenic plants either alone or in combination with other insecticidal proteins. Specific chitinases may prove to be useful as biocontrol agents and/or as vaccines. |
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Authors:
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Yasuyuki Arakane; Subbaratnam Muthukrishnan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-10-09 |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 67 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 201-16 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Kansas State University, 141 Chalmers Hall, Manhattan, KS 66506-3702, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Chitinase* / chemistry, classification, genetics Conserved Sequence Gene Expression Regulation, Enzymologic Insect Control* Insects / enzymology* Molecular Sequence Data Pesticides / metabolism Plants, Genetically Modified / enzymology, genetics Protein Structure, Tertiary Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Pesticides; EC 3.2.1.14/Chitinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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