| Inotropic response of the neonatal canine myocardium to dopamine. | |
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MedLine Citation:
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PMID: 643376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inotropic responsiveness of the developing myocardium to dopamine and isoproterenol was evaluated using isolated, perfused ventricles and atrial strips from puppies ages 15 hr to 33 days. Responses were compared to those in adult animals. The maximum percentage of increase of left ventricular dF/dt increased from 12 +/- 5 (mean +/- SEM) at 0-7 days (n = 6) to 100 +/- 40 at 21-33 days (n = 3) of postnatal age. At 7-14 days (n = 4) and 15-20 days (n = 5) of age the maximum percentage of increase of left ventricular dF/dt was 28 +/- 10 and 39 +/- 17, respectively. Puppy ventricle responded to isoproterenol at all ages equally (maximum percentage increase of left ventricular dF/dt = 46 +/- 13). Atrial muscle strips from puppies, ages 15 hr to 35 days (n = 22), and adult dogs (n = 19) demonstrated equal responsiveness to dopamine as well as to isoproterenol. The maximum percentage of increase of dF/dt was 117 +/- 18 with dopamine. Maximum percentage of increase of dF/dt with dopamine after propranolol (10(-7) M) was 52 +/- 18. Haloperidol (1.10(-7)-2.10(-6) M) did not alter responsiveness of atria to dopamine. |
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Authors:
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D J Driscoll; P C Gillette; E G Ezrailson; A Schwartz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 12 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1978 Jan |
Date Detail:
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Created Date: 1978-06-17 Completed Date: 1978-06-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 42-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Dogs Dopamine / pharmacology* Heart Atria / analysis Heart Ventricles / analysis Isoproterenol / pharmacology Myocardial Contraction / drug effects* Propranolol / pharmacology Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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