| Inotropic effects of gaseous transmitters in isolated rat heart preparation. | |
| | |
MedLine Citation:
|
PMID: 23113302 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10(-5) M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10(-4), 3×10(-4) M). Sodium hydrosulfide (10(-4)-4×10(-4) M) decreased all the parameters of left-ventricular contractive activity and reduced contraction rate. Carbon monoxide and hydrogen sulfide, which together with nitrogen oxide are qualified as a new class of gaseous signal compounds, may substantially modulate pumping function of the heart. |
| | |
Authors:
|
M V Porokhya; D V Abramochkin; A A Abramov; V S Kuzmin; G S Sukhova |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Bulletin of experimental biology and medicine Volume: 153 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
|
Languages: eng; rus Pagination: 855-7 Citation Subset: IM |
Affiliation:
|
Department of Human and Animal Physiology, M.V.Lomonosov Moscow State University, Moscow, Russia. abram340@mail.ru. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of the Cholecystokinin System in Anxiolytic Activity of Dipeptide GB-115.
Next Document: Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepat...