Document Detail


Inotropic and chronotropic activity of a new cardiotonic agent, DM 9278 (1,2,3,4,8,9,10,12-octahydro[2,1-b]pyrido[2,3-f]quinazolin-9-one ), on isolated dog atrial and ventricular muscles.
MedLine Citation:
PMID:  3761569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiac effects of DM9278 were studied in isolated and blood-perfused atrial and ventricular preparations from mongrel dogs. In spontaneously beating isolated right atria, DM9278 caused positive chronotropic and inotropic responses in a dose-related manner (1-100 micrograms). DM9278 produced relatively larger positive inotropic than positive chronotropic effects as compared with effects of aminophylline or papaverine. DM9278 increased the developed tension in left ventricles electrically driven at 1.5-2.0 Hz. Positive inotropic and chronotropic responses to DM9278 in both atrial and ventricular preparations were suppressed slightly but not significantly by 1-3 micrograms of propranolol, which completely blocked the positive chronotropic and inotropic effects of norepinephrine (0.01-0.1 micrograms). From these results, it is concluded that DM9278 has direct cardiotonic properties in isolated dog heart tissues, showing relatively selective positive inotropic activity.
Authors:
S Chiba; Y Furukawa; K Saegusa; Y Ogiwara
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  27     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-11-20     Completed Date:  1986-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / pharmacology*
Dogs
Female
Heart Rate / drug effects*
Male
Myocardial Contraction / drug effects*
Quinazolines / pharmacology*
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Quinazolines; 91599-59-6/DM 9278

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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