Document Detail

Inotropic agents and infarct size. Theoretical and practical considerations.
MedLine Citation:
PMID:  1258787     Owner:  NLM     Status:  MEDLINE    
Recent data demonstrating the ability of interventions that alter the balance between myocardial oxygen demand and supply to affect infarct size are reviewed. The effects of inotropic agents on the determinants of myocardial oxygen consumption and coronary blood flow are discussed relative to the potential of these drugs to decrease or increase infarct size in the experimental animal and in man. The applicability of the animal data to the clinical situation is discussed and, on the basis of these considerations, guidelines are presented for the use of inotropic agents in patients with acute myocardial infarction.
M Lesch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  37     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  508-13     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Cardiac Volume / drug effects
Digitalis Glycosides / pharmacology*
Heart / physiopathology
Heart Rate / drug effects
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects*
Myocardial Infarction / complications,  metabolism,  pathology*
Norepinephrine / pharmacology*
Oxygen / blood
Oxygen Consumption / drug effects
Reg. No./Substance:
0/Digitalis Glycosides; 51-41-2/Norepinephrine; 7683-59-2/Isoproterenol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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