Document Detail

Inotropic agents and functional recovery from ischemic cardiac arrest.
MedLine Citation:
PMID:  462463     Owner:  NLM     Status:  MEDLINE    
Short periods of ischemic arrest may cause myocardial cell damage so that reperfusion does not result in an immediate return to normal metabolic and contractile activity. Studies have been carried out using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest in order to determine whether the use of inotropic agents (isoprenaline and dobutamine) to augment contractile activity during the early phase of post-ischemic reperfusion extends pre-existing damage and results in ultimate impairment of contractile activity. The results indicated the existance of a substantial metabolic reserve, capable of providing sufficient energy for a marked increase in dP/dt and heart rate, without inducing tissue damage. However, in this isolated rat heart preparation the use of these agents had relatively little effect upon cardiac output and could be shown to induce a dose-dependent reduction in stroke volume.
D J Hearse; D A Stewart; M V Braimbridge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  27     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
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MeSH Terms
Cardiopulmonary Bypass
Catecholamines / pharmacology*
Disease Models, Animal
Dobutamine / pharmacology*
Heart / physiopathology
Heart Arrest / physiopathology*
Heart Arrest, Induced
Heart Rate / drug effects
Hemodynamics / drug effects
Isoproterenol / pharmacology*
Myocardial Contraction / drug effects*
Regeneration / drug effects
Reg. No./Substance:
0/Catecholamines; 34368-04-2/Dobutamine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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