Document Detail

Inotropes in preterm infants--evidence for and against.
MedLine Citation:
PMID:  22404887     Owner:  NLM     Status:  MEDLINE    
There is significant uncertainty regarding the optimal circulatory management of preterm infants, with research in the field limited by the paucity of safe, reproducible biomarkers of circulatory function. This review discusses the physiology and pathophysiology of circulatory function in preterm infants, describes the mode of action and evidence for and against commonly used and recently trialled inotropic therapies and provides recommendations for managing circulatory dysfunction in the transitional period and in the context of sepsis/necrotizing enterocolitis. We recommend a pragmatic approach of assessing multiple aspects of circulatory function (blood pressure alone correlates weakly with volume of flow) in each infant, tailoring therapy on the basis of the change in function desired and frequently reassessing response to intervention.
David J Cox; Alan M Groves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992). Supplement     Volume:  101     ISSN:  0803-5326     ISO Abbreviation:  Acta Paediatr Suppl     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-06-25     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9315043     Medline TA:  Acta Paediatr Suppl     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
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MeSH Terms
Biological Markers
Blood Pressure / drug effects*
Cardiotonic Agents / therapeutic use*
Hypotension / drug therapy*
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / drug therapy*,  physiopathology
Sepsis / drug therapy*
Shock / prevention & control*
Grant Support
G0701896//Medical Research Council
Reg. No./Substance:
0/Biological Markers; 0/Cardiotonic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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