Document Detail


Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin.
MedLine Citation:
PMID:  15745806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine inositol tripyrophosphate (ITPP) salts have been synthesized. Their ability to act as allosteric effectors of haemoglobin (Hb) has been measured in vitro with free Hb and whole blood. All the synthesized compounds bound to free Hb and were also able to cross, to a certain extent, the plasma membrane of the red blood cells (RBCs) in whole blood samples, lowering the affinity of Hb for oxygen. The oxy-haemoglobin dissociation curves were significantly shifted towards higher values of oxygen partial pressures, both for free Hb and for intracellular Hb in whole blood.
Authors:
Konstantina C Fylaktakidou; Jean-Marie Lehn; Ruth Greferath; Claude Nicolau
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  15     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-04     Completed Date:  2005-07-12     Revised Date:  2007-01-30    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1605-8     Citation Subset:  IM    
Affiliation:
Laboratoire de Chimie Supramoléculaire, ISIS-Université Louis Pasteur, 8, Allée Gaspard Monge, BP 70028, 67083 Strasbourg cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Allosteric Regulation
Animals
Erythrocyte Membrane / metabolism
Hemoglobins / chemistry,  drug effects*
Humans
Inositol Phosphates / blood,  chemical synthesis*,  pharmacology
Oxyhemoglobins / chemistry
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Inositol Phosphates; 0/Oxyhemoglobins; 0/inositol trispyrophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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