| Inositol supplementation in respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 2117207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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According to preliminary results inositol (INO) is an important nutrient to immature preterm infants (J Pediatr 1987; 110:604). However, it is absent in nutrition of critically ill very low birth weight infants. In a present randomized double blind trial INO or glucose (70-100 mg/kg/day) was given to altogether 230 preterm infants (gestation 24 to 31 w, mean 27.8 w, mean BW 1,106 g) with RDS during 5 neonatal days. Two more courses during the first month were given, if the infant remained respirator-dependent and did not tolerate breast milk. INO-supplemented infants tended to have a milder respiratory course during the first week than those on glucose. The surviving INO-treated infants had a lower incidence of bronchopulmonary dysplasia (BPD) than the controls (p less than 0.01). No infant receiving INO had severe retinopathy (gr 4), whereas of the surviving placebo treated infants 8.8% became blind (p less than 0.005). Inositol promotes endothelial cell growth, enhances glucocorticoid-mediated lung epithelial cell differentiation, and may serve as an antioxidant. INO should be seriously considered as a nutrient during compromised neonatal transition of very low birth weight infants. |
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Authors:
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M Hallman; M Pohjavuori; K Bry |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Lung Volume: 168 Suppl ISSN: 0341-2040 ISO Abbreviation: Lung Publication Date: 1990 |
Date Detail:
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Created Date: 1990-09-20 Completed Date: 1990-09-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 877-82 Citation Subset: IM |
Affiliation:
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Children's Hospital, University of Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cause of Death Double-Blind Method Female Follow-Up Studies Humans Infant Infant, Newborn Inositol / administration & dosage* Male Randomized Controlled Trials as Topic Respiratory Distress Syndrome, Newborn / mortality, therapy* |
| Chemical | |
Reg. No./Substance:
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6917-35-7/Inositol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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