Document Detail


Inositol supplementation in respiratory distress syndrome.
MedLine Citation:
PMID:  2117207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to preliminary results inositol (INO) is an important nutrient to immature preterm infants (J Pediatr 1987; 110:604). However, it is absent in nutrition of critically ill very low birth weight infants. In a present randomized double blind trial INO or glucose (70-100 mg/kg/day) was given to altogether 230 preterm infants (gestation 24 to 31 w, mean 27.8 w, mean BW 1,106 g) with RDS during 5 neonatal days. Two more courses during the first month were given, if the infant remained respirator-dependent and did not tolerate breast milk. INO-supplemented infants tended to have a milder respiratory course during the first week than those on glucose. The surviving INO-treated infants had a lower incidence of bronchopulmonary dysplasia (BPD) than the controls (p less than 0.01). No infant receiving INO had severe retinopathy (gr 4), whereas of the surviving placebo treated infants 8.8% became blind (p less than 0.005). Inositol promotes endothelial cell growth, enhances glucocorticoid-mediated lung epithelial cell differentiation, and may serve as an antioxidant. INO should be seriously considered as a nutrient during compromised neonatal transition of very low birth weight infants.
Authors:
M Hallman; M Pohjavuori; K Bry
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lung     Volume:  168 Suppl     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-82     Citation Subset:  IM    
Affiliation:
Children's Hospital, University of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Cause of Death
Double-Blind Method
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Inositol / administration & dosage*
Male
Randomized Controlled Trials as Topic
Respiratory Distress Syndrome, Newborn / mortality,  therapy*
Chemical
Reg. No./Substance:
6917-35-7/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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