Document Detail

Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes.
MedLine Citation:
PMID:  19494026     Owner:  NLM     Status:  MEDLINE    
Nonglucose carbohydrates such as mannose and inositol are important in early growth and development, although little is known about their metabolism. Our aim in this study was to determine the plasma appearance rates (Ra) for mannose and inositol in newborns as an index of utilization and as an improved guide to supplementation practices. We studied late-preterm (n = 9) and term (n = 5) infants (median 34 wk gestation, range 33-41 wk) using a multiple isotope infusion start time protocol to determine Ra for each carbohydrate. The plasma mannose concentration [median (range)] was 69.83 (48.60-111.75) micromol/L and the Ra was 0.59 (0.42-0.98) micromol x kg(-1) x min(-1) (854 micromol x kg(-1) x d(-1)). The plasma inositol concentration was 175.74 (59.71-300.60) micromol/L and Ra was 1.06 (0.33-1.75) micromol x kg(-1).min(-1) (1521 micromol x kg(-1) x d(-1)). The Ra for mannose and inositol are >10-fold higher than the amounts a breast-fed infant typically ingests, which are approximately 6 micromol x kg(-1) x d(-1) mannose and 150 micromol x kg(-1) x d(-1) inositol. Thus, for both mannose and inositol, the newborn infant must produce these compounds from glucose at rates sufficient to meet nutritional requirements.
Laura D Brown; Alex Cheung; Jeri E F Harwood; Frederick C Battaglia
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Publication Detail:
Type:  Journal Article     Date:  2009-06-03
Journal Detail:
Title:  The Journal of nutrition     Volume:  139     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-09-17     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1648-52     Citation Subset:  IM    
Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.
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MeSH Terms
Blood Glucose / metabolism
Breast Feeding
Dietary Carbohydrates / administration & dosage,  metabolism*
Gestational Age
Infant Formula / metabolism*
Infant Nutritional Physiological Phenomena*
Infant, Newborn / metabolism*
Infant, Premature / metabolism
Infusions, Intravenous
Inositol / administration & dosage,  blood*,  metabolism
Mannose / administration & dosage,  blood*,  metabolism
Milk, Human / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 31103-86-3/Mannose; 6917-35-7/Inositol
Comment In:
J Nutr. 2009 Sep;139(9):1611-2   [PMID:  19605527 ]

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