Document Detail

Inositol and glucocorticoid in the development of lung stability in male and female rabbit fetuses.
MedLine Citation:
PMID:  3205616     Owner:  NLM     Status:  MEDLINE    
Inasmuch as inositol affects the development of lung surfactant, and exogenous glucocorticoids accelerate fetal lung maturation, a possible interaction of the two substances on alveolar stability of preterm rabbit fetuses of 28 days gestation was investigated. On days 26 and 27 of gestation inositol or glucose were added to the diet of does treated with betamethasone (0.2 mg/kg intramuscularly on days 26 and 27). Inositol increased lung-thorax compliance of paralyzed fetuses at all insufflation pressures studied (from 16 to 22.5 and 30 cm H2O and back to 22.5, and 16 cm H2O). At a ventilation pressure of 30 cm H2O, lung-thorax compliance of fetuses treated with inositol plus betamethasone was more than doubled as compared with controls (1.2 +/- 0.6 versus 0.5 +/- 0.2 ml/kg x cm H2O; p less than 0.001). Inositol alone had no detectable effect on compliance, whereas betamethasone tended to increase compliance (p = 0.05). According to variance analysis, the effect of inositol was statistically significant only among the males. Inositol prevented the glucocorticoid-induced decrease in lung protein and, to a lesser extent, the decrease in DNA. Inositol did not further increase the lavageable surfactant pool of the glucocorticoid-treated, ventilated fetuses, although the area occupied by lamellar bodies within type II cells was increased after inositol plus betamethasone. According to the present study, inositol modifies the physiologic and biochemical response of the immature fetal lung to a pharmacologic dose of exogenous glucocorticoid.
M M Anceschi; A Petrelli; G Zaccardo; A Barbati; G C Di Renzo; E V Cosmi; M Hallman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  24     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Institute of Gynecology and Obstetrics, University Perugia, Policlinico Monteluce, Italy.
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MeSH Terms
Betamethasone / pharmacology*
Body Weight
Fetal Organ Maturity / drug effects*
Glucose / pharmacology
Inositol / pharmacology*
Lung / embryology*
Sex Factors
Reg. No./Substance:
378-44-9/Betamethasone; 50-99-7/Glucose; 6917-35-7/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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