Document Detail


Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight.
MedLine Citation:
PMID:  20107057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcium (Ca(2+)) signaling is known to regulate the development, maintenance and modulation of activity in neuronal circuits that underlie organismal behavior. In Drosophila, intracellular Ca(2+) signaling by the inositol 1,4,5-trisphosphate receptor and the store-operated channel (dOrai) regulates the formation and function of neuronal circuits that control flight. Here, we show that restoring InsP(3)R activity in insulin-producing neurons of flightless InsP(3)R mutants (itpr) during pupal development can rescue systemic flight ability. Expression of the store operated Ca(2+) entry (SOCE) regulator dSTIM in insulin-producing neurons also suppresses compromised flight ability of InsP(3)R mutants suggesting that SOCE can compensate for impaired InsP(3)R function. Despite restricted expression of wild-type InsP(3)R and dSTIM in insulin-producing neurons, a global restoration of SOCE and store Ca(2+) is observed in primary neuronal cultures from the itpr mutant. These results suggest that restoring InsP(3)R-mediated Ca(2+) release and SOCE in a limited subset of neuromodulatory cells can influence systemic behaviors such as flight by regulating intracellular Ca(2+) homeostasis in a large population of neurons through a non-cell-autonomous mechanism.
Authors:
Neha Agrawal; Gayatri Venkiteswaran; Sufia Sadaf; Nisha Padmanabhan; Santanu Banerjee; Gaiti Hasan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1301-13     Citation Subset:  IM    
Affiliation:
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Calcium Signaling / physiology*
Cell Membrane / genetics,  metabolism
Cells, Cultured
Central Nervous System / cytology,  growth & development,  metabolism*
Drosophila
Drosophila Proteins / genetics,  metabolism*
Flight, Animal / physiology
Homeostasis / physiology
Inositol 1,4,5-Trisphosphate Receptors / genetics,  metabolism*
Insulin / metabolism*,  secretion
Intracellular Fluid / metabolism
Membrane Proteins / genetics,  metabolism*
Mutation / genetics
Neural Pathways / cytology,  growth & development,  metabolism
Neurons / cytology,  metabolism*,  secretion
Pupa / genetics,  growth & development,  metabolism
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Inositol 1,4,5-Trisphosphate Receptors; 0/Membrane Proteins; 0/STIM1 protein, Drosophila; 11061-68-0/Insulin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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