| Inosiplex for treatment of alopecia areata: a randomized placebo-controlled study. | |
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MedLine Citation:
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PMID: 16955187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment of alopecia areata remains unsatisfactory. We decided to test if systemic therapy with inosiplex (Isoprinosine(R)), an immunomodulator could influence the disease. Thirty-two subjects with recalcitrant alopecia areata, aged 16-48 years (mean 30.3+/-5.1 years), were randomized into two treatment groups of 16 subjects each. They were assigned to receive either oral inosiplex (group 1), or placebo (group 2) on a double-blind basis. Inosiplex dosage was 50 mg/kg/day in five divided doses for 12 weeks. Of the 15 evaluable patients in group 1, 5 (33.3%) had full remission, 8 (53.3%) responded partially and 2 (13.3%) did not respond. Of the 14 evaluable patients in the placebo group, none had full remission, 4 (28.5%) responded partially and 10 (71.4%) did not respond. The therapeutic difference between patients receiving active and placebo therapy was statistically significant (?2=7.82, p<0.01). Compared with placebo, oral inosiplex showed considerable efficacy in alopecia areata with insignificant side-effects. Larger studies are required, however, before inosiplex may be recommended as an efficacious and safe alternative systemic form of therapy for recalcitrant alopecia areata. |
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Authors:
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Sofia Georgala; Alexander C Katoulis; Angeliki Befon; Katerina Georgala; Panagiotis G Stavropoulos |
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Publication Detail:
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Type: Randomized Controlled Trial |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 86 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-09-06 Completed Date: 2006-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Norway |
Other Details:
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Languages: eng Pagination: 422-4 Citation Subset: IM |
Affiliation:
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1st Department of Dermatology and Venereology, A. Sygros Hospital, 5 Dragoumi Street, GR-16121 Athens, Greece. lapidg7@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alopecia Areata / drug therapy* Double-Blind Method Female Humans Inosine Pranobex / administration & dosage, therapeutic use* Male |
| Chemical | |
Reg. No./Substance:
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36703-88-5/Inosine Pranobex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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