Document Detail

Inosiplex for treatment of alopecia areata: a randomized placebo-controlled study.
MedLine Citation:
PMID:  16955187     Owner:  NLM     Status:  MEDLINE    
Treatment of alopecia areata remains unsatisfactory. We decided to test if systemic therapy with inosiplex (Isoprinosine(R)), an immunomodulator could influence the disease. Thirty-two subjects with recalcitrant alopecia areata, aged 16-48 years (mean 30.3+/-5.1 years), were randomized into two treatment groups of 16 subjects each. They were assigned to receive either oral inosiplex (group 1), or placebo (group 2) on a double-blind basis. Inosiplex dosage was 50 mg/kg/day in five divided doses for 12 weeks. Of the 15 evaluable patients in group 1, 5 (33.3%) had full remission, 8 (53.3%) responded partially and 2 (13.3%) did not respond. Of the 14 evaluable patients in the placebo group, none had full remission, 4 (28.5%) responded partially and 10 (71.4%) did not respond. The therapeutic difference between patients receiving active and placebo therapy was statistically significant (?2=7.82, p<0.01). Compared with placebo, oral inosiplex showed considerable efficacy in alopecia areata with insignificant side-effects. Larger studies are required, however, before inosiplex may be recommended as an efficacious and safe alternative systemic form of therapy for recalcitrant alopecia areata.
Sofia Georgala; Alexander C Katoulis; Angeliki Befon; Katerina Georgala; Panagiotis G Stavropoulos
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Publication Detail:
Type:  Randomized Controlled Trial    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  86     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  422-4     Citation Subset:  IM    
1st Department of Dermatology and Venereology, A. Sygros Hospital, 5 Dragoumi Street, GR-16121 Athens, Greece.
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MeSH Terms
Alopecia Areata / drug therapy*
Double-Blind Method
Inosine Pranobex / administration & dosage,  therapeutic use*
Reg. No./Substance:
36703-88-5/Inosine Pranobex

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