Document Detail

Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality.
MedLine Citation:
PMID:  23303729     Owner:  NLM     Status:  MEDLINE    
Inorganic nanocrystals have myriad applications in medicine, including their use as drug or gene delivery complexes, therapeutic hyperthermia agents, in diagnostic systems and as contrast agents in a wide range of medical imaging techniques. In MRI, nanocrystals can produce contrast themselves, with iron oxides having been the most extensively explored, or can be given a coating that generates MR contrast, for example gold nanoparticles coated with gadolinium chelates. These MR-active nanocrystals can be used for imaging of the vasculature, liver and other organs, as well as molecular imaging, cell tracking and theranostics. As a result of these exciting applications, the synthesis and rendering of these nanocrystals as water soluble and biocompatible are therefore highly desirable. We discuss aqueous phase and organic phase methods for the synthesis of inorganic nanocrystals, such as gold, iron oxides and quantum dots. The pros and cons of the various methods are highlighted. We explore various methods for making nanocrystals biocompatible, i.e. direct synthesis of nanocrystals coated with biocompatible coatings, ligand substitution, amphiphile coating and embedding in carrier matrices that can be made biocompatible. Various examples are highlighted and their applications explained. These examples signify that the synthesis of biocompatible nanocrystals with controlled properties has been achieved by numerous research groups and can be applied to a wide range of applications. Therefore, we expect to see reports of preclinical applications of ever more complex MRI-active nanoparticles and their wider exploitation, as well as in novel clinical settings.
David P Cormode; Brenda L Sanchez-Gaytan; Aneta J Mieszawska; Zahi A Fayad; Willem J M Mulder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-10
Journal Detail:
Title:  NMR in biomedicine     Volume:  26     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-20     Completed Date:  2014-01-13     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  766-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
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MeSH Terms
Biocompatible Materials / chemical synthesis
Contrast Media / chemical synthesis*,  chemistry*,  diagnostic use
Hydrophobic and Hydrophilic Interactions
Inorganic Chemicals / chemical synthesis*,  chemistry*,  diagnostic use
Magnetic Resonance Imaging*
Nanoparticles / chemistry*,  ultrastructure
Grant Support
HHSN268201000045C/HL/NHLBI NIH HHS; HHSN268201000045C//PHS HHS; R00 EB012165/EB/NIBIB NIH HHS; R00 EB012165/EB/NIBIB NIH HHS; R01 CA155432/CA/NCI NIH HHS; R01 CA155432/CA/NCI NIH HHS; R01 EB009638/EB/NIBIB NIH HHS; R01 EB009638/EB/NIBIB NIH HHS
Reg. No./Substance:
0/Biocompatible Materials; 0/Contrast Media; 0/Inorganic Chemicals

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