| Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. | |
| | |
MedLine Citation:
|
PMID: 21533816 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Arsenic pollution is a major public health problem worldwide. Inorganic arsenic (iAs) is usually more harmful than organic ones. iAs pollution increases the risk of human diseases such as peripheral vascular disease and cancer. However, the toxicological effects of iAs in the brain are mostly unclear. Here, we investigated the toxic effects and possible mechanisms of iAs in the cerebrum of mice after exposure to iAs (0.5 and 5 ppm (mg/l) As(2)O(3), via the drinking water), which was the possible human exposed dose via the ingestion in iAs-contaminated areas, for 6 consecutive weeks. iAs dose-dependently caused an increase of LPO production in the plasma and cerebral cortex. iAs also decreased the reduced glutathione levels and the expressions of NQO1 and GPx mRNA in the cerebral cortex. These impairments in the cerebral cortex caused by iAs exposure were significantly correlated with the accumulation of As. Moreover, iAs induced the production of apoptotic cells and activation of caspase-3, up-regulation of Bax and Bak, and down-regulation of Mcl-1 in the cerebral cortex. Exposure to iAs also triggered the expression of ER stress-related genes, including GRP78, GRP94, and CHOP. Meanwhile, an increase of p38 activation and dephosphorylation of ERK1/2 were shown in the cerebral cortex as a result of iAs-exposed mice. These iAs-induced damages and apoptosis-related signals could be significantly reversed by NAC. Taken together, these results suggest that iAs-induced oxidative stress causes cellular apoptosis in the cerebrum, signaling of p38 and ERK1/2, and ER stress may be involved in iAs-induced cerebral toxicity. |
| | |
Authors:
|
Cheng Chien Yen; Tsung Jung Ho; Chin Ching Wu; Chun Fang Chang; Chin Chuan Su; Ya Wen Chen; Tzyy Rong Jinn; Tien Hui Lu; Po Wen Cheng; Yi Chang Su; Shing Hwa Liu; Chun Fa Huang |
Related Documents
:
|
15664906 - Oral mucosal endotoxin tolerance induction in chronic periodontitis. 21549866 - Copper exposure effects on yeast mitochondrial proteome. 15972526 - Effect of chlamydia pneumoniae on cellular atp content in mouse macrophages: role of to... 17419716 - Lipopolysaccharides from atherosclerosis-associated bacteria antagonize tlr4, induce fo... 18461366 - Suppression of fasl expression in tumor cells and preventing tnf-induced apoptosis was ... 20200406 - Differential effects of selective hdac inhibitors on macrophage inflammatory responses ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-1 |
Journal Detail:
|
Title: Archives of toxicology Volume: - ISSN: 1432-0738 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417615 Medline TA: Arch Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Occupational Safety and Health, College of Health Care and Management, Chung Shan Medical University, No. 110, Sec. 1, Jian-Guo N. Rd., Taichung, 40201, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Variation in circulating corticosterone levels is associated with altitudinal range expansion in a p...
Next Document: Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.