Document Detail

Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
MedLine Citation:
PMID:  20585108     Owner:  NLM     Status:  MEDLINE    
Ingestion of dietary (inorganic) nitrate elevates circulating and tissue levels of nitrite via bioconversion in the entero-salivary circulation. In addition, nitrite is a potent vasodilator in humans, an effect thought to underlie the blood pressure-lowering effects of dietary nitrate (in the form of beetroot juice) ingestion. Whether inorganic nitrate underlies these effects and whether the effects of either naturally occurring dietary nitrate or inorganic nitrate supplementation are dose dependent remain uncertain. Using a randomized crossover study design, we show that nitrate supplementation (KNO(3) capsules: 4 versus 12 mmol [n=6] or 24 mmol of KNO(3) (1488 mg of nitrate) versus 24 mmol of KCl [n=20]) or vegetable intake (250 mL of beetroot juice [5.5 mmol nitrate] versus 250 mL of water [n=9]) causes dose-dependent elevation in plasma nitrite concentration and elevation of cGMP concentration with a consequent decrease in blood pressure in healthy volunteers. In addition, post hoc analysis demonstrates a sex difference in sensitivity to nitrate supplementation dependent on resting baseline blood pressure and plasma nitrite concentration, whereby blood pressure is decreased in male volunteers, with higher baseline blood pressure and lower plasma nitrite concentration but not in female volunteers. Our findings demonstrate dose-dependent decreases in blood pressure and vasoprotection after inorganic nitrate ingestion in the form of either supplementation or by dietary elevation. In addition, our post hoc analyses intimate sex differences in nitrate processing involving the entero-salivary circulation that are likely to be major contributing factors to the lower blood pressures and the vasoprotective phenotype of premenopausal women.
Vikas Kapil; Alexandra B Milsom; Michael Okorie; Sheiva Maleki-Toyserkani; Farihah Akram; Farkhanda Rehman; Shah Arghandawi; Vanessa Pearl; Nigel Benjamin; Stavros Loukogeorgakis; Raymond Macallister; Adrian J Hobbs; Andrew J Webb; Amrita Ahluwalia
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-28
Journal Detail:
Title:  Hypertension     Volume:  56     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-08-10     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  274-81     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Brachial Artery / anatomy & histology,  drug effects,  physiology
Cardiovascular Diseases / epidemiology
Cross-Over Studies
Cyclic GMP / blood
Double-Blind Method
Heart Rate / drug effects
Hyperemia / physiopathology
Hypertension / complications
Hypotension / chemically induced
Life Style
Nitrates / blood,  pharmacology*
Nitric Oxide / physiology*
Nitrites / blood,  pharmacology
Potassium Chloride / pharmacology
Potassium Compounds / pharmacology*
Random Allocation
Risk Factors
Sex Characteristics
Systole / drug effects,  physiology
Grant Support
SP/08/006/25110//British Heart Foundation; //British Heart Foundation
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 0/Potassium Compounds; 31C4KY9ESH/Nitric Oxide; 660YQ98I10/Potassium Chloride; H2D2X058MU/Cyclic GMP; RU45X2JN0Z/potassium nitrate
Comment In:
Hypertension. 2011 Feb;57(2):e1-2; author reply e3   [PMID:  21135354 ]
Erratum In:
Hypertension. 2010 Sep;56(3):e37-9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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