Document Detail


Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome.
MedLine Citation:
PMID:  3182076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To further elucidate the importance of T- and B-lymphocyte-mediated responses in host defense against systemic infection with Candida albicans, we studied this infection in a murine model of severe combined immunodeficiency (SCID). The course of inoculation candidiasis in these mice, which lack functional T and B lymphocytes, was compared with that in immunologically normal BALB/c mice. Mice were inoculated intravenously with 10(5) yeast cells. Quantitative cultures of liver, spleen, and kidneys were performed with necropsy specimens obtained 1, 3, 7, 10, 14, and 21 days after this intravenous inoculation. The differences in the time courses of recovery of organisms from liver and spleen specimens were not significantly different in the SCID mice compared with the BALB/c mice. The recovery of C. albicans from the kidneys was significantly lower in the SCID mice, indicating less persistence of the organism in the kidneys of the SCID mice than in those of the BALB/c mice. These data indicate that defense mechanisms other than T- and B-lymphocyte-mediated mechanisms are primarily responsible for host defense against inoculation candidiasis.
Authors:
S Mahanty; R A Greenfield; W A Joyce; P W Kincade
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  56     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1988-12-20     Completed Date:  1988-12-20     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3162-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.
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MeSH Terms
Descriptor/Qualifier:
Animals
Candidiasis / immunology*,  microbiology
Disease Models, Animal / immunology*
Immunologic Deficiency Syndromes / immunology*
Kidney / microbiology
Liver / microbiology
Mice
Mice, Mutant Strains
Spleen / microbiology
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