| Inoculation of Staphylococcus xylosus in SJL/J mice to determine pathogenicity. | |
| | |
MedLine Citation:
|
PMID: 12906403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An experimental study was performed to investigate whether intradermal tail inoculations of Staphylococcus xylosus would result in pathologic lesions in the SJL/J strain of mice (Mus musculus). This organism historically has been classified as a nonpathogenic, commensal bacterium associated with skin and mucous membranes and rarely implicated in infections. In this study, SJL/J mice inoculated with S. xylosus developed cutaneous tail lesions post-inoculation, and the organism was recovered from those lesions. Inoculation was accomplished by surgically inserting silk suture impregnated with the concentrated suspension of bacteria. In addition, a superficial abrasion was created adjacent to the suture, and a bacterial suspension was applied. Approximately 80% of the mice in the inoculated groups developed dermatologic lesions, compared with 0% in the control group. Mice with lesions were treated with Sulfamethoxazole-Trimethoprim in the drinking water continuously for 28 days. For the mice assigned to the treatment group, this treatment resulted in resolution of the cutaneous tail lesions. |
| | |
Authors:
|
Venita B Thornton; Judith A Davis; Mark B St Clair; Marlene N Cole |
Related Documents
:
|
3599883 - The role of klebsiella oxytoca in utero-ovarian infection of b6c3f1 mice. 8408163 - Biologic response modifier ok-432 pretreatment reduces mortality in burned mice infecte... 23648663 - In vivo activity of ursolic and oleanolic acids during the acute phase of trypanosoma c... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science Volume: 42 ISSN: 1060-0558 ISO Abbreviation: Contemp Top Lab Anim Sci Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-08-08 Completed Date: 2003-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204153 Medline TA: Contemp Top Lab Anim Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 49-52 Citation Subset: IM |
Affiliation:
|
Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Bacterial Agents / therapeutic use Female Mice Mice, Inbred Strains Opportunistic Infections* Specific Pathogen-Free Organisms Staphylococcal Skin Infections / drug therapy, microbiology*, pathology Staphylococcus / classification, pathogenicity* Treatment Outcome Trimethoprim-Sulfamethoxazole Combination / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of coinfection with pinworms (Aspiculuris tetraptera, Dentostomella translucida, and Syph...
Next Document: An alternative method of chronic cerebrospinal fluid collection via the cisterna magna in conscious ...