Document Detail

Inoculation of Staphylococcus xylosus in SJL/J mice to determine pathogenicity.
MedLine Citation:
PMID:  12906403     Owner:  NLM     Status:  MEDLINE    
An experimental study was performed to investigate whether intradermal tail inoculations of Staphylococcus xylosus would result in pathologic lesions in the SJL/J strain of mice (Mus musculus). This organism historically has been classified as a nonpathogenic, commensal bacterium associated with skin and mucous membranes and rarely implicated in infections. In this study, SJL/J mice inoculated with S. xylosus developed cutaneous tail lesions post-inoculation, and the organism was recovered from those lesions. Inoculation was accomplished by surgically inserting silk suture impregnated with the concentrated suspension of bacteria. In addition, a superficial abrasion was created adjacent to the suture, and a bacterial suspension was applied. Approximately 80% of the mice in the inoculated groups developed dermatologic lesions, compared with 0% in the control group. Mice with lesions were treated with Sulfamethoxazole-Trimethoprim in the drinking water continuously for 28 days. For the mice assigned to the treatment group, this treatment resulted in resolution of the cutaneous tail lesions.
Venita B Thornton; Judith A Davis; Mark B St Clair; Marlene N Cole
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science     Volume:  42     ISSN:  1060-0558     ISO Abbreviation:  Contemp Top Lab Anim Sci     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204153     Medline TA:  Contemp Top Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Mice, Inbred Strains
Opportunistic Infections*
Specific Pathogen-Free Organisms
Staphylococcal Skin Infections / drug therapy,  microbiology*,  pathology
Staphylococcus / classification,  pathogenicity*
Treatment Outcome
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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