Document Detail

Innovations in siRNA research: a technology comes of age.
MedLine Citation:
PMID:  20812899     Owner:  NLM     Status:  MEDLINE    
Short interfering RNAs, or siRNAs, belong to a class of RNA species which play a role in both cellular defence and gene regulation. siRNAs comprise a larger portion of the RNA interference pathway that includes the degradation of RNAs which possess complementarily to specific target sequences. This property has given siRNA technology the potential to become a powerful new tool for a wide variety of disciplines, ranging from the design of novel anti-cancer agents to applications in agriculture. The following review outlines patents that have been issued over the past 6 months concerning siRNA technology. Patents are discussed which encompass improved delivery systems for cellular uptake of siRNAs, new therapeutics to combat human diseases, and unique uses of siRNAs to advance plant science. The review also provides detailed lists of the most recent patents that have been issued which cover these areas of siRNA technology, and paves the way for future innovations based on RNA interference in the life sciences.
Kathleen L Hefferon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent patents on anti-infective drug discovery     Volume:  5     ISSN:  1574-891X     ISO Abbreviation:  Recent Pat Antiinfect Drug Discov     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-09-29     Revised Date:  2012-05-02    
Medline Journal Info:
Nlm Unique ID:  101266084     Medline TA:  Recent Pat Antiinfect Drug Discov     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  226-39     Citation Subset:  IM    
Cornell Research Foundation 395 Pine Tree Rd, Suite 310, Cornell University Ithaca, NY 14850, USA.
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MeSH Terms
Gene Therapy / legislation & jurisprudence,  methods,  trends*
Gene Transfer Techniques / trends*
Patents as Topic / legislation & jurisprudence
RNA, Small Interfering / administration & dosage,  genetics*,  therapeutic use*
Reg. No./Substance:
0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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