Document Detail


Innervation of somatostatin synthesizing neurons by adrenergic, phenylethanolamine-N-methyltransferase (PNMT)-immunoreactive axons in the anterior periventricular nucleus of the rat hypothalamus.
MedLine Citation:
PMID:  1972144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adrenergic innervation of somatostatin synthesizing neurons located in the anterior region of the rat hypothalamic periventricular nucleus was studied by means of a light and electron microscopic immunocytochemical double labelling technique. This region which is the source of hypophysiotrophic somatostatin immunoreactive (IR) neurons also receives a dense plexus of adrenergic axons as determined by immunocytochemistry of phenylethanolamine-N-methyltransferase (PNMT), the marker enzyme for the central adrenergic system. The simultaneous detection of PNMT and somatostatin antigens in hypothalamic sections of colchicine pretreated animals revealed a congruency in the distribution of the labelled elements and also close juxtaposition of PNMT-IR axons to somatostatin producing neurons. At the ultrastructural level, axo-somatic and axo-dendritic synaptic connections were found between PNMT-containing axons and somatostatin expressing neurons. These morphological findings support the view that the central adrenergic system might influence the production and secretion of growth hormone in the pituitary gland by a direct monosynaptic interaction with somatostatin synthesizing neurons.
Authors:
Z Liposits; I Kalló; M Barkovics-Kalló; M C Bohn; W K Paull
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Histochemistry     Volume:  94     ISSN:  0301-5564     ISO Abbreviation:  Histochemistry     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-18     Completed Date:  1990-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0411300     Medline TA:  Histochemistry     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  13-20     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University Medical School, Pécs, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / analysis*,  ultrastructure
Animals
Axons / analysis,  enzymology,  ultrastructure
Hypothalamus, Anterior / analysis*,  enzymology,  ultrastructure
Immunohistochemistry
Male
Microscopy, Electron
Neurons / analysis*,  enzymology,  ultrastructure
Phenylethanolamine N-Methyltransferase / analysis*
Rats
Rats, Inbred Strains
Somatostatin / analysis*
Grant Support
ID/Acronym/Agency:
NS 19266/NS/NINDS NIH HHS; NS 20832/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
51110-01-1/Somatostatin; EC 2.1.1.28/Phenylethanolamine N-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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