| Innervation of somatostatin synthesizing neurons by adrenergic, phenylethanolamine-N-methyltransferase (PNMT)-immunoreactive axons in the anterior periventricular nucleus of the rat hypothalamus. | |
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MedLine Citation:
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PMID: 1972144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The adrenergic innervation of somatostatin synthesizing neurons located in the anterior region of the rat hypothalamic periventricular nucleus was studied by means of a light and electron microscopic immunocytochemical double labelling technique. This region which is the source of hypophysiotrophic somatostatin immunoreactive (IR) neurons also receives a dense plexus of adrenergic axons as determined by immunocytochemistry of phenylethanolamine-N-methyltransferase (PNMT), the marker enzyme for the central adrenergic system. The simultaneous detection of PNMT and somatostatin antigens in hypothalamic sections of colchicine pretreated animals revealed a congruency in the distribution of the labelled elements and also close juxtaposition of PNMT-IR axons to somatostatin producing neurons. At the ultrastructural level, axo-somatic and axo-dendritic synaptic connections were found between PNMT-containing axons and somatostatin expressing neurons. These morphological findings support the view that the central adrenergic system might influence the production and secretion of growth hormone in the pituitary gland by a direct monosynaptic interaction with somatostatin synthesizing neurons. |
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Authors:
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Z Liposits; I Kalló; M Barkovics-Kalló; M C Bohn; W K Paull |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Histochemistry Volume: 94 ISSN: 0301-5564 ISO Abbreviation: Histochemistry Publication Date: 1990 |
Date Detail:
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Created Date: 1990-07-18 Completed Date: 1990-07-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0411300 Medline TA: Histochemistry Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Department of Anatomy, University Medical School, Pécs, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Fibers
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analysis*,
ultrastructure Animals Axons / analysis, enzymology, ultrastructure Hypothalamus, Anterior / analysis*, enzymology, ultrastructure Immunohistochemistry Male Microscopy, Electron Neurons / analysis*, enzymology, ultrastructure Phenylethanolamine N-Methyltransferase / analysis* Rats Rats, Inbred Strains Somatostatin / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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NS 19266/NS/NINDS NIH HHS; NS 20832/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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51110-01-1/Somatostatin; EC 2.1.1.28/Phenylethanolamine N-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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