| The inner segment/outer segment border seen on optical coherence tomography is less intense in patients with diminished cone function. | |
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MedLine Citation:
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PMID: 22110066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Horizontal line scans through the fovea of 30 healthy controls, 10 patients with achromatopsia (A), and six with cone dystrophy (CD) were obtained with frequency domain (fd) OCT. The fdOCT borders were segmented with a computer-aided manual technique. The ISe was divided into regions 60.1 μm wide and 19.5 μm deep. The relative ISe intensity of each region was defined as its intensity divided by the intensity of a local region, which extended in depth from the choroid to the retinal ganglion cell/retinal nerve fiber layer. RESULTS: Except for the central fovea, all patients had a clear ISe band across the region studied, ± 3 mm from the foveal center. However, the relative ISe intensity was significantly lower (P < 0.0001) in patients (A: 1.14 ± 0.14; CD: 1.27 ± 0.14), than in controls (1.61 ± 0.16). There were no differences in the relative intensity of the other retinal layers. CONCLUSIONS: Although present, the intensity of this ISe band is lower in patients with diminished cone function than it is in healthy controls. This is consistent with the hypothesis that both rod and cone receptors must be absent or damaged for the ISe band to be missing. |
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Authors:
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Donald C Hood; Xian Zhang; Rithambara Ramachandran; Christine L Talamini; Ali Raza; Jonathan P Greenberg; Jerome Sherman; Stephen H Tsang; David G Birch |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-12-28 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-29 Completed Date: 2012-03-01 Revised Date: 2012-05-10 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 9703-9 Citation Subset: IM |
Affiliation:
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Department of Psychology, Columbia University, New York, New York 10027, USA. dch3@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Color Vision Defects / diagnosis* Electroretinography Humans Ophthalmoscopy Retinal Cone Photoreceptor Cells / pathology* Retinal Dystrophies / diagnosis* Retinal Photoreceptor Cell Inner Segment / pathology* Retinal Photoreceptor Cell Outer Segment / pathology* Tomography, Optical Coherence* |
| Grant Support | |
ID/Acronym/Agency:
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EY-018213/EY/NEI NIH HHS; P30-EY-019007/EY/NEI NIH HHS; R01-EY-09076/EY/NEI NIH HHS |
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