| Innate signaling networks in mucosal IgA class switching. | |
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MedLine Citation:
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PMID: 21034970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production. |
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Authors:
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Alejo Chorny; Irene Puga; Andrea Cerutti |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in immunology Volume: 107 ISSN: 1557-8445 ISO Abbreviation: Adv. Immunol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2011-02-14 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0370425 Medline TA: Adv Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 31-69 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immunity, Innate Immunity, Mucosal / genetics, immunology* Immunoglobulin A, Secretory / genetics, immunology* Immunoglobulin Class Switching / genetics, immunology* Intestinal Mucosa / immunology* Signal Transduction / genetics, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI-05753/AI/NIAID NIH HHS; R01 AI-074378/AI/NIAID NIH HHS; R01 AI057653-05/AI/NIAID NIH HHS; R01 AI074378/AI/NIAID NIH HHS; R01 AI074378-01A1/AI/NIAID NIH HHS; R01 AI074378-02/AI/NIAID NIH HHS; R01 AI074378-03/AI/NIAID NIH HHS; R01 AI074378-04/AI/NIAID NIH HHS; R01 AI074378-05/AI/NIAID NIH HHS; R01 AI074378-06/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A, Secretory |
| Comments/Corrections | |
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