| Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants. | |
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MedLine Citation:
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PMID: 14638628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that human milk fucosyloligosaccharides are part of an innate immune system, we addressed whether their expression (1) depends on maternal genotype and (2) protects breastfed infants from pathogens. Thus the relationship between maternal Lewis blood group type and milk oligosaccharide expression and between variable oligosaccharide expression and risk of diarrhea in their infants was studied in a cohort of 93 Mexican breastfeeding mother-infant pairs. Milk of the 67 Le(a-b+) mothers contained more LNF-II (Le(a)) and 3-FL (Le(x)) (oligosaccharides whose fucose is exclusively alpha 1,3- or alpha 1,4-linked) than milk from the 24 Le(a-b-) mothers; milk from Le(a-b-) mothers contained more LNF-I (H-1) and 2'-FL (H-2), whose fucose is exclusively alpha 1,2-linked. The pattern of oligosaccharides varied among milk samples; in each milk sample, the pattern was summarized as a ratio of 2-linked to non-2-linked fucosyloligosaccharides. Milks with the highest ratios were produced primarily by Le(a-b-) mothers; those with the lowest ratios were produced exclusively by Le(a-b+) mothers (p<0.001). Thus maternal genetic polymorphisms expressed as Lewis blood group types are expressed in milk as varied fucosyloligosaccharide ratios. The four infants who developed diarrhea associated with stable toxin of Escherichia coli were consuming milk with lower ratios (4.4 +/- 0.8 [SE]) than the remaining infants (8.5 +/- 0.8; p<0.001). Furthermore, the 27 infants who developed moderate to severe diarrhea of any cause were consuming milk with lower ratios (6.1 +/- 0.9) than the 26 who remained healthy (10.5 +/- 1.9; p = 0.042). Thus, milk with higher 2-linked to non-2-linked fucosyloligosaccharide ratios affords greater protection against infant diarrhea. We conclude that specific oligosaccharides constitute a major element of an innate immune system of human milk. |
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Authors:
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David S Newburg; Guillermo M Ruiz-Palacios; Mekibib Altaye; Prasoon Chaturvedi; Jareen Meinzen-Derr; Maria de Lourdes Guerrero; Ardythe L Morrow |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2003-11-24 |
Journal Detail:
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Title: Glycobiology Volume: 14 ISSN: 0959-6658 ISO Abbreviation: Glycobiology Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-02-18 Completed Date: 2004-10-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9104124 Medline TA: Glycobiology Country: England |
Other Details:
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Languages: eng Pagination: 253-63 Citation Subset: IM |
Affiliation:
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Program in Glycobiology, Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452,USA. david.newburg@umassmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Feeding* / adverse effects Chromatography, High Pressure Liquid Cohort Studies Diarrhea / immunology*, prevention & control* Female Follow-Up Studies Humans Infant Infant, Newborn Lewis Blood-Group System / analysis Milk, Human / chemistry*, immunology* Oligosaccharides / analysis, chemistry*, immunology* Phenotype |
| Grant Support | |
ID/Acronym/Agency:
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HD13021/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lewis Blood-Group System; 0/Oligosaccharides |
| Comments/Corrections | |
Erratum In:
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Glycobiology. 2004 May;14(5):13G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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