Document Detail


Innate inflammation as the common pathway of risk factors leading to TIAs and stroke.
MedLine Citation:
PMID:  20955419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the early moments of ischemic stroke, the processes of thrombosis, ischemia, and inflammation are intimately interrelated, setting in motion an injury that leads to infarction and permanent damage. Of these, the potential roles that innate inflammation can play in the evolution of brain tissue damage in response to the ischemic injury are not well understood. Observations in the settings of atherosclerotic cardiovascular disease and cerebral ischemia have much to teach each other. The following provides an introductory overview of the conference "Innate Inflammation as the Common Pathway of Risk Factors Leading to Transient Ischemic Attacks and Stroke: Pathophysiology and Potential Interventions," which took place May 9-10, 2010 at the New York Academy of Sciences. This meeting was convened to explore aspects of the cellular and tissue responses to innate inflammation. A faculty of leading experts was assembled to discuss the role of inflammation in laboratory models of stroke and myocardial infarction, define possible novel means from laboratory evidence to alleviate or prevent inflammation underlying stroke and cardiovascular disease, and present information on current examples of clinical translation of these understandings in relation to human stroke and myocardial infarction.
Authors:
Gregory J del Zoppo; Philip B Gorelick
Related Documents :
17596689 - Effect of the ca antagonist nilvadipine on stroke occurrence or recurrence and extensio...
15465079 - Influence of pretreatment mri parameters on clinical outcome, recanalization and infarc...
12417359 - Stroke vs. chronic progressive cerebrovascular disease: a magnetic resonance imaging st...
20589199 - Carotid intima-media thickness, not carotid plaque, is associated with large territory ...
8268869 - Hypertension studies in china.
18597839 - Does differential prophylactic aspirin use contribute to racial and geographic disparit...
14564229 - New concepts in post-infarction ventricular remodeling.
7049099 - Hypothermic ischemic arrest versus hypothermic potassium cardioplegia in human beings.
7079459 - Effect of local ischaemia on the myocardial oxygen balance and its response to heart ra...
Publication Detail:
Type:  Introductory Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1207     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-10     Citation Subset:  IM    
Copyright Information:
© 2010 New York Academy of Sciences.
Affiliation:
Division of Hematology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA. grgdlzop@u.washington.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Immunity, Innate
Inflammation / complications*,  physiopathology
Ischemic Attack, Transient / etiology*
Risk Factors
Stroke / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How inflammation modulates central nervous system vessel activation and provides targets for interve...
Next Document:  Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke.