| Innate immunity of the liver microcirculation. | |
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MedLine Citation:
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PMID: 21049273 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The liver is a complex organ with a unique microcirculation and both synthetic and immune functions. Innate immune responses have been studied in response to single inflammatory mediators and several clinically relevant models of infection and injury. While standard histological techniques have been used in many models, the liver microcirculation is also amenable to in vivo examination using epifluorescent, confocal and transillumination intravital microscopy. These techniques have begun to clarify not only the molecular mechanisms but also the specific cell populations involved in the liver inflammation. In this review, we discuss the cells and mediators involved in hepatic innate immunity in simple and complex models of injury and infection, and present the view that the liver microcirculation utilizes non-classical pathways for leukocyte recruitment. |
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Authors:
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Paulina M Kowalewska; Amanda L Patrick; Alison E Fox-Robichaud |
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Publication Detail:
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Type: Journal Article Date: 2010-10-30 |
Journal Detail:
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Title: Cell and tissue research Volume: 343 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 85-96 Citation Subset: IM |
Affiliation:
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Department of Medicine, McMaster University, Hamilton, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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