| Innate immunity in the human lung: pathogen recognition and lung disease. | |
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MedLine Citation:
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PMID: 20936302 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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As the human lung is exposed to a variety of microbial pathogens in the environment, a first line of defense is built up by pulmonary cells like bronchial/alveolar epithelial cells and alveolar macrophages. These cells express several pattern recognition receptors (PRRs) recognizing highly conserved microbial motifs and initiating the production of chemokines and pro- and anti-inflammatory cytokines acting as transmembrane or intracellular receptors. This might not only lead to acute but also to chronic inflammation which is discussed as an underlying mechanism in the pathogenesis of different lung diseases. |
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Authors:
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Kristina Rohmann; Thomas Tschernig; Reinhard Pabst; Thorsten Goldmann; Daniel Drömann |
Publication Detail:
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Type: Journal Article Date: 2010-10-09 |
Journal Detail:
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Title: Cell and tissue research Volume: 343 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 167-74 Citation Subset: IM |
Affiliation:
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Medical Clinic III, University of Schleswig-Holstein, Campus Lübeck, 23538, Lübeck, Germany. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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