Document Detail


Innate immunity in donor procurement.
MedLine Citation:
PMID:  23313940     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Ischaemic kidney injury occurs during organ procurement and can lead to delayed graft function or nonviable grafts. The innate immune system is a key trigger of inflammation in renal ischaemia. This review discusses the components of innate immunity known to be involved in renal ischaemic reperfusion injury (IRI). Understanding how inflammatory damage is initiated in renal IRI is important for the development of targeted therapies aimed at preserving the donor organ.
RECENT FINDINGS: Much remains to be determined about the role of innate immune signalling in renal ischaemia/reperfusion injury. Recently, discoveries about complement receptors, Toll-like receptors (TLRs), NOD-like receptors (NLRs) and inflammasomes have opened new avenues of exploration. We are also now learning that macrophages, complement and TLR activation may have additional roles in renal repair following IRI.
SUMMARY: A greater understanding of the mechanisms that contribute to innate immune-mediated renal ischaemic damage will allow for the development of therapeutics targeted to the donor organ. New data suggest that treatment limited to specific receptors on specific cells, or localized to specific regions within the kidney, may provide novel approaches to maximize our use of donor organs, particularly those that may have been discarded due to prolonged preimplantation ischaemia.
Authors:
Kitty P Cheung; Sashi G Kasimsetty; Dianne B McKay
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in organ transplantation     Volume:  18     ISSN:  1531-7013     ISO Abbreviation:  Curr Opin Organ Transplant     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-14     Completed Date:  2013-04-25     Revised Date:  2013-07-26    
Medline Journal Info:
Nlm Unique ID:  9717388     Medline TA:  Curr Opin Organ Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-60     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Hypertension, Department of Medicine, University of California at San Diego, La Jolla, California, USA.
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MeSH Terms
Descriptor/Qualifier:
Delayed Graft Function / immunology
Humans
Immunity, Innate / physiology*
Inflammation / immunology
Kidney / immunology
Reperfusion Injury / immunology*
Tissue Donors*
Tissue and Organ Procurement*
Grant Support
ID/Acronym/Agency:
DK091136/DK/NIDDK NIH HHS; R01 DK075718/DK/NIDDK NIH HHS; R01 DK091136/DK/NIDDK NIH HHS; R01 DK75718/DK/NIDDK NIH HHS; T32 HL007261/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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