Document Detail


Innate immune response to viral infection of the lungs.
MedLine Citation:
PMID:  19026365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Viral respiratory tract infections are the most common infectious illnesses, though they are usually self-limiting and confined to the respiratory tract. The rapid identification of viruses and their effective elimination with minimal local and systemic inflammation is a testament to the efficiency of the innate immune response within the airways and lungs. A failure of this response appears to occur in those with asthma and chronic obstructive pulmonary disease, where viral infection is an important trigger for acute exacerbations. The innate immune response to viruses requires their early detection through pathogen recognition receptors and the recruitment of the efficient antiviral response that is centred around the release of type 1 interferons. The airway epithelium provides both a barrier and an early detector for viruses, and interacts closely with cells of the innate immune response, especially macrophages and dendritic cells, to eliminate infection and trigger a specific adaptive immune response.
Authors:
Hayley See; Peter Wark
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-15
Journal Detail:
Title:  Paediatric respiratory reviews     Volume:  9     ISSN:  1526-0550     ISO Abbreviation:  Paediatr Respir Rev     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-26     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  100898941     Medline TA:  Paediatr Respir Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
Affiliation:
Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Australia.
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MeSH Terms
Descriptor/Qualifier:
Dendritic Cells / immunology*
Humans
Immunity, Innate*
Interferon Type I
Lung Diseases / immunology*,  virology
Macrophages, Alveolar / immunology*
Respiratory Mucosa / immunology*
Virus Diseases / immunology*
Chemical
Reg. No./Substance:
0/Interferon Type I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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