Document Detail


Innate immune response to adenovirus.
MedLine Citation:
PMID:  16207466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenovirus is a common infectious pathogen in both children and adults. It is a significant cause of morbidity in immunocompetent people living in crowded living conditions and of mortality in immunocompromised hosts. It has more recently become a popular vehicle for gene therapy applications. The host response to wild-type infection and gene therapy vector exposure involves both the innate and adaptive immune systems. The initial innate immune response is associated with the severe acute manifestations of adenovirus infection and also plays a significant role in acute toxicity owing to adenovirus vector exposure. This review discusses the innate immune response primarily during wild-type adenovirus infection because this serves as the basis for understanding the response during both natural infection and exposure to adenovirus vectors.
Authors:
Shoab A Nazir; Jordan P Metcalf
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  53     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2005-12-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  292-304     Citation Subset:  IM    
Affiliation:
Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA. jordan-metcalf@ouhsc.edu
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MeSH Terms
Descriptor/Qualifier:
Adenovirus Infections, Human / immunology
Adenoviruses, Human / classification,  genetics,  immunology*
Antimicrobial Cationic Peptides / immunology
Cytokines / immunology
Defensins / immunology
Dendritic Cells / immunology
Epithelial Cells / immunology
Gene Therapy
Genetic Vectors
Humans
Immunity, Cellular
Immunity, Innate*
Macrophages / immunology
Neutrophils / immunology
Pulmonary Surfactants / immunology
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Cytokines; 0/Defensins; 0/Pulmonary Surfactants; 143108-26-3/CAP18 lipopolysaccharide-binding protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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