Document Detail

Innate immune response to adenovirus.
MedLine Citation:
PMID:  16207466     Owner:  NLM     Status:  MEDLINE    
Adenovirus is a common infectious pathogen in both children and adults. It is a significant cause of morbidity in immunocompetent people living in crowded living conditions and of mortality in immunocompromised hosts. It has more recently become a popular vehicle for gene therapy applications. The host response to wild-type infection and gene therapy vector exposure involves both the innate and adaptive immune systems. The initial innate immune response is associated with the severe acute manifestations of adenovirus infection and also plays a significant role in acute toxicity owing to adenovirus vector exposure. This review discusses the innate immune response primarily during wild-type adenovirus infection because this serves as the basis for understanding the response during both natural infection and exposure to adenovirus vectors.
Shoab A Nazir; Jordan P Metcalf
Related Documents :
20109126 - Portuguese winemaking residues as a potential source of natural anti-adenoviral agents.
21178416 - The use of nitric oxide releasing nanoparticles as a treatment against acinetobacter ba...
4362916 - Experimental adenovirus infection of the mouse adrenal gland. i. light microscopic obse...
7470836 - Isolation of adenovirus type 19 from the male and female genital tracts.
21923686 - Effects of myeloid differentiation primary response gene 88 (myd88) activation on helic...
24022556 - Pulmonary carcinoid presenting with cavitating lung infection and oligometastatic media...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  53     ISSN:  1081-5589     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2005-12-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  292-304     Citation Subset:  IM    
Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenovirus Infections, Human / immunology
Adenoviruses, Human / classification,  genetics,  immunology*
Antimicrobial Cationic Peptides / immunology
Cytokines / immunology
Defensins / immunology
Dendritic Cells / immunology
Epithelial Cells / immunology
Gene Therapy
Genetic Vectors
Immunity, Cellular
Immunity, Innate*
Macrophages / immunology
Neutrophils / immunology
Pulmonary Surfactants / immunology
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Cytokines; 0/Defensins; 0/Pulmonary Surfactants; 143108-26-3/CAP18 lipopolysaccharide-binding protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interview with Elaine Gallin, program director for medical research at the Doris Duke Charitable Fou...
Next Document:  Attitudes toward hormone replacement therapy in the new millennium: university physicians' and patie...