| Innate immune recognition of nucleic acids: beyond toll-like receptors. | |
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MedLine Citation:
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PMID: 16080197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During infection or tissue damage, the innate immune system detects and responds to nucleic acids released from pathogens or damaged host cells. Accumulating evidence has showed that specific sequences, modifications or structures of nucleic acids influence their immunomodulatory activities. Resulting innate immune modulations are regulated by Toll-like receptor (TLR)-dependent or -independent signaling pathways. The first step in host defense against foreign or unwelcome self nucleic acids may play important roles in immune responses against infectious organisms, as well as in clearance of unnecessary tissues, which may be linked to autoimmune diseases and possibly to other immunological disorders. Elucidating mechanisms of innate immune activation by nucleic acids will help future development of more efficient or safer nucleic acid-based immunotherapies and gene therapies. |
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Authors:
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Ken J Ishii; Shizuo Akira |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 117 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-09-21 Completed Date: 2005-11-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 517-23 Citation Subset: IM |
Copyright Information:
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Copyright 2005 Wiley-Liss, Inc. |
Affiliation:
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Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Osaka. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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CpG Islands
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genetics Humans Immunity, Innate* Membrane Glycoproteins / physiology* Nucleic Acids / immunology* Receptors, Cell Surface / physiology* Toll-Like Receptors |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Nucleic Acids; 0/Receptors, Cell Surface; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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