| Innate immune receptor activation in viral myocarditis: pathophysiologic implications. | |
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MedLine Citation:
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PMID: 20391900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The spectrum of clinical manifestations of viral myocarditis is extensive, ranging from asymptomatic infection to fulminant myocarditis. Viral infection is a major cause of acute myocarditis, with parvovirus B19 and human herpes virus 6 reported as most often responsible for viral myocarditis. The characteristics of the viral agent, together with the host's genetic susceptibility and the variability of the innate immune system, appear to be the main cause of this broad clinical spectrum. In viral infections the host's innate immune system acts as the first line of defense to prevent viral invasion and replication through cellular receptors. In the present review we analyze current knowledge of the activation of Toll-like receptors (TLR). Understanding the exact mechanism by which viral agents activate these receptors may help improve therapeutic strategies for viral myocarditis. TLRs play a dual role in the pathogenesis of viral myocarditis. In some models, through the activation of TLR3, they lead to a reduction of disease by direct or indirect inhibition of viral invasion and replication, while in other models they are responsible for exacerbation of the inflammatory response to viral infection, via activation of TLRs 4, 7, and 8. TLR4 also appears to be involved in activation of the autoimmune response. |
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Authors:
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Patrícia Santos Tavares; Roberto Rocon-Albuquerque; Adelino F Leite-Moreira |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology Volume: 29 ISSN: 0870-2551 ISO Abbreviation: Rev Port Cardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710716 Medline TA: Rev Port Cardiol Country: Portugal |
Other Details:
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Languages: eng; por Pagination: 57-78 Citation Subset: IM |
Affiliation:
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Serviço de Fisiologia, Faculdade de Medicina do Porto, Porto, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases
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immunology Humans Myocarditis / immunology*, physiopathology, virology* Toll-Like Receptors / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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