| Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. | |
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MedLine Citation:
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PMID: 15193289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the expression of pro-inflammatory transcripts was assessed across the brain of mice having undertaken pilocarpine-induced seizures. Pilocarpine-induced marked neurodegeneration and demyelination in multiple regions of the forebrain. The pattern of genes encoding toll-like receptor type 2 (TLR2) and I kappa B alpha (index of NF-kappa B activation) was associated with the neurodegenerating areas, but this was not the case for the mRNA encoding other inflammatory proteins. Scattered tumor necrosis factor-alpha (TNF-alpha)-expressing cells were found across brain, whereas the signals for monocyte-chemoattractant protein-1 and microsomal prostaglandin mPGES E synthase were robust in thalamus and cerebral cortex and weak in the hippocampus and amygdala. TLR2 and TNF-alpha transcripts were expressed mainly in microglia/macrophages. Cyclooxygenase-2 was induced specifically in the hippocampus and piriform cortex. A low increase in interleukin-12 mRNA was detected in the brain, but the signal for interferon gamma (IFN-gamma) remained undetectable. Although pro-inflammatory markers were induced in a different manner across the CNS, their patterns were not characteristic of those caused by other inflammatory challenges, such as endotoxin. These data suggest a different mechanism involved in regulating the innate immune reaction in response to seizures and could have direct implications for the neuropathology associated with epilepsy. |
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Authors:
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Nicolas P Turrin; Serge Rivest |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurobiology of disease Volume: 16 ISSN: 0969-9961 ISO Abbreviation: Neurobiol. Dis. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-14 Completed Date: 2004-08-13 Revised Date: 2010-06-10 |
Medline Journal Info:
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Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
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Languages: eng Pagination: 321-34 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Endocrinology, Department of Anatomy and Physiology, CHUL Research Center, Laval University, Quebec, Canada G1V 4G2. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / immunology*, pathology, physiopathology Cell Death / immunology Cyclooxygenase 2 Cytokines / immunology Demyelinating Diseases / immunology, pathology Epilepsy / chemically induced, immunology*, pathology* Gene Expression / immunology Intramolecular Oxidoreductases / genetics Isoenzymes / genetics Male Membrane Glycoproteins / genetics Mice Mice, Inbred Strains Muscarinic Agonists Neuroimmunomodulation / immunology* Neurons / pathology Phenotype Pilocarpine Prostaglandin-Endoperoxide Synthases / genetics RNA, Messenger / analysis Receptors, Cell Surface / genetics Toll-Like Receptor 2 Toll-Like Receptors |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Isoenzymes; 0/Membrane Glycoproteins; 0/Muscarinic Agonists; 0/RNA, Messenger; 0/Receptors, Cell Surface; 0/Toll-Like Receptor 2; 0/Toll-Like Receptors; 92-13-7/Pilocarpine; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.3/prostaglandin-E synthase |
| Comments/Corrections | |
Comment In:
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Epilepsy Curr. 2006 Jan-Feb;6(1):11-3
[PMID:
16477316
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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